ACTRN12614000695606已完成未知
PRE-TREAT - A window study to determine short-term effects of Pre-operative Treatment with tamoxifen or letrozole on the expression of pro-survival genes in oestrogen receptor (ER) positive breast cancer
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 21
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomised trial
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- Female
入选标准
- •2. Histologically confirmed invasive ductal or lobular carcinoma of the breast
- •3. Consented to Breast Biomarker Project (TransBCR MH HREC No:2013.025)
- •4. Oestrogen-positive breast cancer, defined as ++ to +++, i.e. moderate to strong tumour immunostaining in >20% of the tumour cells
- •5. Intention to treat with surgery
- •6. ECOG 0-1
排除标准
- •1. Known metastatic breast cancer
- •2. Previous invasive carcinoma of the breast
- •3. Pregnancy or lactation
- •4. Subjects deemed to require any neoadjuvant therapy prior to definitive surgery
- •5. Concurrent therapy with a Selective Oestrogen Receptor Modulator (SERM), aromatase inhibitor or pure ER antagonist e.g. fulvestrant
- •6. Prior endocrine therapy or chemotherapy
- •7. Contraindication to tamoxifen use for tamoxifen arm (past or strong family history of venous thromboembolic events, BMI>35, planned surgery >4 hours)
- •8. Current anti-coagulation therapy for thromboembolic event
- •9. History of severe osteoporosis defined by osteoporosis-related fractures or limiting activities of daily living in post-menopausal women
研究者
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