Effect of Non-surgical Periodontal Treatment on Oxidative Stress and Antioxidant Status in Obstructive Sleep Apnea Syndrome (OSAS)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Serum Oxidative Stress Index (OSI) level : TOS/TAS
研究概览
简要总结
The main objective of this study is to compare the effect of the non-surgical periodontal treatment on serum and saliva oxidative stress parameters in patients with periodontitis and obstructive sleep apnea syndrome (OSAS) and in patients with periodontitis only.
详细描述
There is evidence supporting that OSAS is an independent risk factor for cardiovascular and cerebrovascular diseases such as hypertension, congestive heart failure, myocardial infarction, cardiac-arrhythmia, and stroke.Gender, age, smoking, obesity and diabetes, which are risk factors for periodontitis,It is also common in OSAS at the same time.In addition to common risk factors, both OSAS and periodontitis have been shown to be associated with increased oxidative stress markers.
The investigators aimed to investigate whether non-surgical periodontal treatment on serum and saliva oxidative stress parameters in patients with periodontitis and obstructive sleep apnea syndrome (OSAS) and in patients with periodontitis only.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aged ≥18 years old
- •having more than 16 teeth
- •BMI>25 kg/m2
排除标准
- •patients with a history of diabetes mellitus or respiratory diseases
- •patients who were under any medication that was known to influence periodontal tissues
- •patients with a history of any periodontal treatment in the past 6 months
- •patients with hormonal changes such as pregnancy or lactation; and 5) patients having fixed dentures or removable prothesis
- •OSAS treatment started (using OSAS therapy device or undergoing surgical operation)
研究组 & 干预措施
Experimental: Non-surgical periodontal therapy in patient with OSAS and Periodontitis
Non-surgical periodontal therapy consisted of scaling and root planing and supportive periodontal therapy during 3 months Individuals: with both OSAS and periodontitis Intervention: Procedure: Non-surgical periodontal therapy
干预措施: Experimental (Other)
Control: non-surgical periodontal therapy in Periodontitis
Non-surgical periodontal therapy consisted of scaling and root planing and supportive periodontal therapy during 3 months Individuals: only periodontitis Intervention: Procedure: Non-surgical periodontal therapy
干预措施: Control (Other)
结局指标
主要结局
Serum Oxidative Stress Index (OSI) level : TOS/TAS
时间窗: 3 months
Changes in serum and salivary oxidative stress parameters
Saliva Thiol/disulfid (millimolar per liter (mmol /L))
时间窗: 3 months
Changes in serum and salivary oxidative stress parameters
Serum Total Antioxidant Status (TAS) level (millimolar per liter (mmol /L))
时间窗: 3 months
Changes in serum and salivary oxidative stress parameters
Saliva Total Oxidant Status (TOS) level (mikromolar per liter (µmol /L))
时间窗: 3 months
Changes in serum and salivary oxidative stress parameters
Saliva Oxidative Stress Index (OSI) level : TOS/TAS
时间窗: 3 months
Changes in serum and salivary oxidative stress parameters
Serum Total Oxidant Status (TOS) level (mikromolar per liter (µmol /L))
时间窗: 3 months
Changes in serum and salivary oxidative stress parameters
Serum Native Thiol (mikromolar per liter (µmol /L))
时间窗: 3 months
Changes in serum and salivary oxidative stress parameters
Saliva Total Antioxidant Status (TAS) level (millimolar per liter (mmol /L))
时间窗: 3 months
Changes in serum and salivary oxidative stress parameters
Serum Thiol/disulfid (millimolar per liter (mmol /L))
时间窗: 3 months
Changes in serum and salivary oxidative stress parameters
Saliva Native Thiol (mikromolar per liter (µmol /L))
时间窗: 3 months
Changes in serum and salivary oxidative stress parameters
次要结局
- Bleeding on probing (BOP)(3 months)
- Clinical attachment loss(CAL)(3 months)
- Plaque Index (PI)(3 months)
- Probing pocket depth (PD)(3 months)
- Gingival Index (GI)(3 months)