Individualized Precise Localization of rTMS on Primary Motor Area and Its Effects on Basal Ganglia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 38
- 试验地点
- 2
- 主要终点
- degree of enhanced neuro-activity associated with frequency-specific treatment
研究概览
简要总结
Parkinson's disease (PD) patients have some problem with self-initiated movement task. Compared with health controls, task meta-analysis found that PD patients showed abnormal activation in pre-supplementary motor area (pre-SMA) and putamen. And the functional connectivity has already been reported between pre-SMA and putamen in 2013. Repetitive Transcranial Magnetic Stimulation (rTMS) is a sage and painless technique to activate cortical areas. The deep brain structure can be activated via stimulating superficial cortex by rTMS. For investigating the mechanism of self-initiated movement, this project is using functional magnetic resonance imaging (fMRI) to individualize the precise localization in motor area and combining rTMS to activate putamen.
详细描述
Healthy subject is recruiting in this project. High and low frequency rTMS will be performed, respectively. For the l-Hz sessions (low frequency), stimulation is delivered at 100% of the subject's resting motor threshold at 1 Hz continuously over 30 min for a total of 1,800 pluses. The 10-Hz stimulation is delivered at 100% of the subject's resting motor threshold via 60 trains of 3-s 10-Hz rTMS (30 pulses per train).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 19 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •There are activation in motor area during the task fMRI
- •The head motion less than 2 mm in translation or 2 degrees in rotation in any direction during the resting-state fMRI
排除标准
- •Without any neuropsychiatric conditions
- •No head injury or history of epilepsy
- •Not on any medications
研究组 & 干预措施
Real rTMS (low frequency)
Real rTMS (low frequency) is 1Hz.
干预措施: rTMS (Device)
Sham rTMS
Sham rTMS session includes low frequency and high frequency stimulations.
干预措施: rTMS (Device)
Real rTMS (high frequency)
Real rTMS (high frequency) is 10Hz.
干预措施: rTMS (Device)
结局指标
主要结局
degree of enhanced neuro-activity associated with frequency-specific treatment
时间窗: through study completion, an average of 1 year
functional connectivity
次要结局
未报告次要终点
研究者
Yu-Feng ZANG
Professor
Hangzhou Normal University