跳至主要内容
临床试验/NCT01899586
NCT01899586已完成不适用

Mechanisms and Functional Outcomes of Exercise Progression Models in the Elderly

Duke University4 个研究点 分布在 1 个国家目标入组 108 人开始时间: 2009年9月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
108
试验地点
4
主要终点
Change In Exercise Capacity

研究概览

简要总结

The aim of this study is to devise a sufficiently high intensity training program that provided an optimal stimulus to remove the peripheral factors known to reduce functional capacity, and can be cardiovascular and orthopedically well tolerated by the elderly. Findings from study laboratories have suggested that a regional specific training stimulus (RSTS) results in rapid improvements in both vascular and muscular function. RSTS is a novel combination of resistance training and aerobic training applied simultaneously, and in a serial manner, to specific regions of the body. It involves high-intensity and frequency muscle contractions, generating a targeted exercise stimulus, without producing excessive cardiovascular or orthopedic stress. The hypothesis is that initiating training with RSTS at multiple, strategically selected peripheral sites, in a serial manner will elicit local vascular and muscular changes, thereby preparing individuals at elevated risk of losing independence, to respond and progress more favorably to whole-body exercise.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
70 Years 至 —(Older Adult)
性别
All
接受健康志愿者

入选标准

  • >70 yrs of age
  • Sedentary (exercising <1 day/wk)
  • Non-smokers
  • Able to ambulate without use of an assistive device
  • Able to walk between 200-450m on a 6-minute walk test

排除标准

  • Oxygen dependent
  • Recent medications changes (within 3 months)
  • Current Smokers
  • Fixed-rate pacemakers
  • Uncontrolled hypertension or Type II diabetes
  • Positive ECG changes or angina during CPX testing
  • Unable to complete a maximal CPX to volitional fatigue
  • AHA Class D, or NYHA Class III or IV heart failure

结局指标

主要结局

Change In Exercise Capacity

时间窗: Baseline, 4 weeks, and 12 weeks

Exercise capacity was assessed using a maximal cardiopulmonary exercise (CPX) test with expired gas analysis, for determination of peak oxygen consumption and peak walking time.

Change in Maximal Strength

时间窗: Baseline, 4 weeks, and 12 weeks

Skeletal muscle strength was assessed using a one repetition maximum (1RM) measurement obtained for the seated row, chest press, leg press and handgrip.

次要结局

  • Change in Skeletal Muscle Physiology(Baseline, 4 weeks, and 12 weeks)
  • Change in Functional Ability(Baseline, 4 weeks and 12 Weeks)
  • Change In Vascular Function(Baseline, 4 weeks, and 12 weeks)

研究者

发起方
Duke University
申办方类型
Other
责任方
Sponsor

研究点 (4)

Loading locations...

相似试验