EUCTR2020-003140-83-NL进行中（未招募）1 期
A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of NBI-921352 as Adjunctive Therapy in Subjects with SCN8A Developmental and Epileptic Encephalopathy Syndrome (SCN8A-DEE)
eurocrine Biosciences, Inc.0 个研究点目标入组 60 人开始时间: 2021年11月11日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •Be a male or female 12 to 21 years of age, inclusive.
- •Have a diagnosis of SCN8A-DEE supported by both clinical and genetic findings
- •Have on average at least 1 countable motor seizure per week and not be seizure-free for more than 20 consecutive days.
- •Being treated with at least 1 other ASM, but no more than 4 ASMs.
- •Have failed to achieve seizure freedom with at least 2 ASMs.
- •Must be using a nocturnal alerting system or practice consistent with standards of care at the time of screening and continue to use this for the duration of the study.
- •Must have an adequate rescue medication regimen per the investigator’s judgment in place at the time of screening and for the duration of the study.
- •Have a body weight of at least 10 kg
- •The subject's parent/caregiver is able to accurately identify seizure types, especially countable motor seizures and is able to complete seizure diary
- •Are the trial subjects under 18? yes
- •Number of subjects for this age range: 23
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 7
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •Have previously been enrolled in this study and received blinded treatment.
- •Have participated in an interventional clinical trial <30 days prior to screening.
- •Have symptoms that would be more consistent with another epilepsy disorder such as Dravet syndrome (eg, fever-induced episodes of status epilepticus, frequent myoclonic seizures, worsening on sodium channel blockers, absence seizures with generalized spike-and-wave EEG as the sole seizure type).
- •Are currently receiving cannabinoids or medical marijuana except Epidiolex/Epidyolex, unless approved by the Sponsor.
- •Are currently taking systemic steroids (excluding inhaled medication for asthma treatments). If subject has received these medications in the past, must be off these medications for at least 3 months prior to the screening visit and these drugs may not be initiated during the duration of the study. Intermittent steroids to treat nonepilepsy related diseases (such as allergies or dermatological conditions) are not exclusionary.
- •Have a history of moderate or severe head trauma or other neurological disorders or systemic medical diseases that are, in the investigator’s opinion, likely to affect nervous system functioning.
- •Have a clinically significant medical condition or chronic disease that in the opinion of the investigator would preclude the subject from participating in and completing the study or that could confound interpretation of study outcome.
- •Have clinically significant abnormal vital signs at the screening visit as determined by the investigator.
- •Have one or more clinical laboratory test values outside the reference range, based on blood samples taken at the screening visit, that are of potential risk to the subject’s safety
- •Have, at the screening visit, an ECG finding of a corrected QT interval using Fridericia’s formula (QTcF) >450 msec or presence of any significant cardiac abnormality.
研究者
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