ISRCTN33084113已完成不适用
A two-centre randomised controlled trial investigating the effect of remote ischaemic preconditioning (RIPC) on blood and myocardial biomarkers of stress and injury-related signalling in patients having isolated coronary artery bypass grafting (CABG) or aortic valve replacement (AVR) using cardiopulmonary bypass (CPB)
Imperial College London (UK)0 个研究点目标入组 120 人开始时间: 2013年3月25日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
研究概览
简要总结
- 2015 protocol in: http://www.ncbi.nlm.nih.gov/pubmed/25899533 2. 2018 results in https://www.ncbi.nlm.nih.gov/pubmed/30544237
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Current inclusion criteria as of 03/11/2014:
- •1. Age =18
- •2. Patients undergoing elective (or urgent) first-time CABG or AVR
- •Previous inclusion criteria:
- •1. Male and female, age >=40 and <85 years
- •2. Patients undergoing elective (or urgent) first-time CABG or AVR
排除标准
- •Current exclusion criteria as of 03/11/2014:
- •1. Cardiogenic shock or cardiac arrest,
- •2. Significant peripheral arterial disease affecting upper limbs,
- •3. Renal failure (with a GFR < 30 ml/min/1.73m2),
- •4. Glibenclamide or nicorandil (as these medications may interfere with RIPC)
- •5. Participation in another interventional study.
- •6. Neither upper limb available for the intervention
- •Previous exclusion criteria:
- •1. Cardiogenic shock or cardiac arrest
- •2. Significant peripheral arterial disease affecting upper limbs
- •3. Hepatic dysfunction (Bilirubin > 20 mmol/L, Prothrombin > 2.0 ratio)
- •4. Pulmonary disease (FEV1 < 40% predicted)
- •5. Renal failure (with a GFR < 30 ml/min/1.73m2)
- •6. Glibenclamide or nicorandil (as these medications may interfere with RIPC)
- •7. Participation in another interventional study
研究者
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