Bone Mass Changes in Anorexia Nervosa Patient Followed During 4 Years and Relationship Between Bone Loss and Adipokines.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Bone mineral density by Dual Energy X-ray Absorptiometry (DEXA)
研究概览
简要总结
The mechanism of bone loss in anorexia nervosa is complex. Marrow adipose tissue seems to play a role in the regulation of bone metabolism. Adipocytes secrete cytokines and adipokines that either stimulate or inhibit adjacent osteoblasts. This study consist to explore the relationship in anorexia nervosa patients with change in bone mineral density and adipokines like leptin, adiponectin and Préf-1 Bone mineral densities will be measure in 180 anorexia nervosa patients at inclusion and every two years during 6 years.It is assessed blood and urinary calcium and phosphate levels, bone remodelling markers and adipokines (leptin, adiponectin and Préf-1)
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •anorexia patient defined by DSM IV diagnostic criteria
排除标准
- •patient with other psychiatric disease
- •patient with other a metabolic bone disease
结局指标
主要结局
Bone mineral density by Dual Energy X-ray Absorptiometry (DEXA)
时间窗: 4 years
measured the evolution of the bone mineral density in 180 anorexia nervosa patients and the relationship with this change and adipokine
次要结局
- Adiponectin plasma concentration by ELISA(at 2,4 and 6 years)
- Incidence of osteoporotic fractures(at 2,4 and 6 years)
- Interleukin-7 plasma concentration by ELISA(at 2,4 and 6 years)