Cough in Eastern and Central Finland
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 61
- 试验地点
- 2
- 主要终点
- Receiver operator characteristic curves of the citric acid and the mannitol aerosol bronchial challenges
研究概览
简要总结
Comparison of citric acid and mannitol cough provocation tests among subjects with chronic cough and healthy volunteers.
详细描述
35 subjects with chronic cough plus 25 subjects without any cough will be asked to participate. The study consists of two visits in the outpatient clinic of Kuopio University Hospital, department of respiratory medicine, 2 - 7 days apart. They will fill in the Leicester Cough Questionnaire and undergo two different cough provocation tests, in random order: Mannitol test and citric acid test. If a chest x-ray has not been taken within 6 months, it will be taken.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •, Chronic cough patients:
- •(both criteria must be fulfilled)
- •presence of current chronic cough (> 8 weeks)
- •Leicester Cough Questionnaire total score < 17
- •Inclusion criteria, healthy volunteers
- •absence of any form of cough
排除标准
- •age < 18 years
- •any disability which would challenge the subject's ability to understand the purpose and methods of the study
- •pregnancy
- •breastfeeding
- •current smoking or ex smoking more than 10 pack years
- •any thoracic x-ray finding indicating urgent mediacal interventions
研究组 & 干预措施
Citric acid aerosol bronchial challenge
Inhaled citric acid aerosol. This study investigates the diagnostic accuracy of two cough provocation tests, one of which is citric acid aerosol challenge.
干预措施: Citric acid aerosol bronchial challenge (Diagnostic Test)
Mannitol aerosol bronchial challenge
Inhaled mannitol aerosol. This study investigates the diagnostic accuracy of two cough provocation tests, one of which is mannitol aerosol challenge.
干预措施: Mannitol aerosol bronchial challenge (Diagnostic Test)
结局指标
主要结局
Receiver operator characteristic curves of the citric acid and the mannitol aerosol bronchial challenges
时间窗: Within one week from the start of the study in each individual
Receiver operator characteristic curve describes the ability of the bronchial challenge to separate the cough patients from healthy volunteers
次要结局
- Leicester Cough Questionnaire total score(The first study day)
研究者
Heikki Koskela
Professor
Kuopio University Hospital