Study to Analyze the Predictive Role of Factors Implicated in the Signaling Pathway of the EGFR in Response to Treatment With Neoadjuvant Chemoradiotherapy in Patients With Cancer of the Esophagus or Rectum
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Determination of predictive factors in the EGFR signaling pathway in response to treatment
研究概览
简要总结
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.
PURPOSE: This clinical trial is studying how well biological factors work in predicting response to treatment in patients with esophageal cancer or rectal cancer.
详细描述
OBJECTIVES:
Primary
- Analyze various biological factors that can be used as markers to predict response to treatment and correlate with the signaling pathway of EGFR.
Secondary
- Establish a tissue bank to store information about the response to treatment and survival.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 120 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DISEASE CHARACTERISTICS:
- •Histologically confirmed adenocarcinoma or squamous cell carcinoma of the esophagus or rectum
- •Planning to receive neoadjuvant treatment, including radiotherapy or chemoradiotherapy
- •PATIENT CHARACTERISTICS:
- •Not pregnant or nursing
- •No blood disorder
- •Not deprived of freedom or protected by law
- •PRIOR CONCURRENT THERAPY:
- •See Disease Characteristics
排除标准
- 未提供
研究组 & 干预措施
Experimental: Rectal and oesophagus cancer
Additionnal samples from routine care (tumor tissue and healthy tissue and one blood tube) and standardized clinical data will be entered into a database.
干预措施: Gene expression analysis (Genetic)
结局指标
主要结局
Determination of predictive factors in the EGFR signaling pathway in response to treatment
时间窗: End of study : approximately 4 years
次要结局
未报告次要终点