NCT01217346终止不适用
A Prevalence Study of Obstructive Sleep Apnea in Subjects With Chest Pain, Positive Exercise Treadmill Test and Normal Coronary Angiogram
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- apnea hypopnea index
研究概览
简要总结
Cardiac syndrome X consists of a triad of chest pain, abnormal exercise stress testing and normal coronary angiogram, and is hypothesized to be related to endothelial dysfunction. Endothelial dysfunction is also reported to be linked to obstructive sleep apnea. While chest pain can be one of potential presenting symptoms of obstructive sleep apnea, the investigators hypothesize that obstructive sleep apnea is common in subjects with cardiac syndrome X.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≧18 years, < 70 years
- •Symptom of chest pain occurring at least once in the preceding year
- •Positive exercise treadmill test
- •Negative coronary angiogram
- •Mentally fit to give informed consent
排除标准
- •Mentally incapacitated persons
- •Congestive heart failure
- •Other potential causes of orthopnea (severe chronic obstructive pulmonary disease, persistent asthma)
结局指标
主要结局
apnea hypopnea index
时间窗: measure at a single time point when the subjects are admitted for overnight polysomnography
assess apnea hypopnea index by overnight polysomnography, by a single admission to sleep laboratory
次要结局
- endothelial function(measured at a single time point when the subjects are admitted for overnight polysomnography)
研究者
研究点 (1)
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