Modulation of Olfactory Valence by Transcranial Focused Ultrasound (tFUS)
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 28
研究概览
简要总结
This study investigates the causal effects of low-intensity transcranial focused ultrasound (tFUS) on odor valence perception and odor-elicited avoidance behaviors in healthy adults. Participants undergo sham and active tFUS targeting the amygdala (AMYG) and ventral striatal olfactory tubercle (VSOT) in a within-subject, randomized, sham-controlled crossover design. Outcomes include subjective odor ratings and objective neurophysiological and behavioral indices of odor valence processing. This research is exploratory and mechanistic in nature and is not intended to evaluate clinical safety or therapeutic efficacy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-65 years
- •Healthy adult volunteers
- •Normal olfactory function (Sniffin' Sticks total TDI ≥ 30.75)
- •Ability to provide informed consent
- •English fluency sufficient for task completion
排除标准
- •MRI or tFUS contraindications (e.g., metal implants, claustrophobia, pregnancy)
- •Sinonasal conditions affecting airflow or smell
- •Current use of medications that alter olfaction
- •Positive urine drug screen
研究组 & 干预措施
Active tFUS targeting the Amygdala (AMYG)
Active tFUS of the bilateral Amygdala randomized at one of the three stimulation visits
干预措施: transcranial focused ultrasound (tFUS) (Device)
Active tFUS targeting the Ventral Striatal Olfactory Tubercle (VSOT)
Active tFUS of the bilateral VSOT randomized at one of the three stimulation visits
干预措施: transcranial focused ultrasound (tFUS) (Device)
Sham tFUS
Sham tFUS randomized at one of three stimulation visits
干预措施: transcranial focused ultrasound (tFUS) (Device)
研究者
Bernadette Cortese
Associate Professor-Faculty
Medical University of South Carolina