Optimal duration of dual antiplatelet therapy after stent-assisted coiling of unruptured intracranial aneurysms: A prospective randomized multicenter trial

Seoul National University Bundang Hospital0 个研究点目标入组 528 人开始时间: 待定最近更新: 2024年6月24日

适应症

试验速览

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•1) Adults aged 19 years or older
•2) Those who plans to perform coil embolization under stent-assisted unruptured cerebral aneurysm, and the number of platelets measured before the procedure corresponds to the following conditions:
•a) aspirin reaction unit (ARU) < 550
•b) P2Y12 reaction unit (PRU): 85~219
•3) Modified Rankin Scale (mRS) Score= 2 at the screening
•4) Those who has fully understand to the explanation of this study and has finally agreed.

•1) Those who have neurological disabilities at the cerebral aneurysm procedure (mRS 3) 3)
•2) Those who are allergic to aspirin and clopidogrel.
•3) Those who have a high risk of excessive bleeding when taking medication, such as internal bleeding or severe stomach ulcers.
•4) Those with bleeding tendency or blood clotting problems
•5) Those who need to maintain anticoagulants or double antiplatelet treatment due to existing diseases such as cardiovascular disease (excluding patients who have maintained aspirin at mono and patients who need to maintain dual antiPLTs.)
•6) Those at high risk of stroke (such as Moyamoya disease, cerebrovascular abnormalities, etc. in cases of atrial fibrillation patients requiring double antiplatelets or anticoagulants, intracranial or intravascular obstruction or more than 70% stenosis).
•7) Those who have uncontrolled heart failure or angina.
•8) Those with a malignant tumor that needs treatment
•9) Those who are pregnant or breastfeeding.
•10) Those who are unconscious at the time of diagnosis
•11) Those with platelet reduction (<100,000/mm3)
•12) Those with liver diseases (AST or ALT > 100 IU/L)
•13) Kidney problem patients (Creatinine> 2 mg/dL; dialysis patients are excluded)
•14) No regular follow-up observation is possible.
•15) Those with medical conditions for which the expected dawn is less than two years.
•16) Those deemed ineligible for this study by investigators

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