NCT00757978已完成4 期
Phase 4 Memantine as Adjunctive Therapy for Schizophrenia Negative Symptoms in Patients Using Clozapine. A Randomized, Double-Blind, Placebo Controled Study
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Score in Brief Psychiatric Raring Scale
研究概览
简要总结
Memantine as an add-on therapy to clozapine may improve schizophrenia negative symptoms and cognitive functioning.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Under clozapine with negative symptoms
排除标准
- •Pregnancy
- •Lactation
研究组 & 干预措施
1
Placebo Comparator
Clozapine plus placebo
干预措施: placebo (Drug)
2
Active Comparator
Clozapine plus memantine
干预措施: memantine (Drug)
结局指标
主要结局
Score in Brief Psychiatric Raring Scale
时间窗: baseline, 4 weeks, 8 weeks, 12 weeks
次要结局
未报告次要终点
研究者
研究点 (1)
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