Safety and Effectiveness of Resveratrol in Promoting Sirtuin 1 Activation and Enhancing Health in Elderly Adults: A Prospective Interventional Approach

Summary****IntroductionAging leads to a decline in organ function, contributing to chronic illnesses such as diabetes, Alzheimer’s, and heart disease. Cellular senescence, oxidative stress, and mitochondrial dysfunction accelerate aging. Resveratrol, a polyphenol with antioxidant and anti-inflammatory properties, activates the SIRT1 pathway, potentially improving mitochondrial function and reducing oxidative stress. This study aims to assess whether resveratrol can enhance cognitive function and physical health in elderly adults.

Methodology

• Study Design: Prospective interventional study.
• Inclusion Criteria: Elderly adults (60–75 years), stable diabetic or hypertensive patients, willing to give consent.
• Exclusion Criteria: Severe cardiac or respiratory dysfunction, high liver enzyme levels, chronic alcohol/drug abuse, cognitive impairment, or previous resveratrol use.
• Intervention: 500 mg/day of Resveratrol.
• Assessments:
• Baseline and follow-up assessments at 45 and 90 days.
• SIRT1 expression levels.
• Six-minute walk test (6MWT) for physical capacity.
• Montreal Cognitive Assessment (MoCA) for cognitive function.
• Quality of life (EuroQol-5D-5L).
• Adverse event monitoring. Need for StudyWith increasing elderly populations, research on safe anti-aging interventions is crucial. Resveratrol has shown promising results in improving mitochondrial function, reducing inflammation, and potentially mitigating age-related diseases. This study aims to provide evidence of its effectiveness in real-world clinical settings.

Procedure

1. Screening & Enrollment: Participants are selected based on inclusion and exclusion criteria.
2. Baseline Assessment: Demographics, SIRT1 levels, 6MWT, MoCA, and quality of life scores are recorded.
3. Intervention: Daily 500 mg resveratrol supplementation with adherence monitoring.
4. Follow-ups (Day 45 & 90): Reassessment of key parameters and adverse event reporting.
5. Statistical Analysis: Paired t-test to compare changes in key outcomes.