A Phase 3, Randomized, Double-blind, Efficacy and Safety Study Comparing Orelabrutinib to Placebo in Patients With Non-active Secondary Progressive Multiple Sclerosis
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 990
- 试验地点
- 45
- 主要终点
- Time to onset of confirmed disability progression (CDP) events, confirmed over at least 24 weeks
研究概览
简要总结
Orelabrutinib is a CNS-penetrable BTK inhibitor. This is a phase 3, randomized, double-blind, parallel-group, multicenter study to evaluate the efficacy and safety of orelabrutinib compared with placebo in patients with non-active Secondary Progress MS. Patients will be treated for approximately 24 to 60 months, with a minimum treatment duration of 12 months. The study will enroll approximately 990 subjects in a 2:1 randomization (orelabrutinib: placebo), globally.
详细描述
This is a phase 3, randomized, double-blind, parallel-group, multicenter study to evaluate the efficacy and safety of orelabrutinib compared with placebo in patients with naSPMS. The study will enroll approximately 990 subjects in a 2:1 randomization (orelabrutinib: placebo), globally.
The study consists of the following periods:
- Screening Period: Up to 4 weeks.
- Treatment Period: The duration of treatment will vary for individual participants ranging from approximately 24 to 60 months, depending on the time of recruitment. A month is defined as a period of 28 days by convention.
- Double-blinded (DB) Treatment: All eligible participants will be randomized at 2:1 ratio to accept orelabrutinib QD or placebo during the DB treatment period. The study will be unblinded when all participants in the DB period have reached a minimum treatment duration of 12 months at the time of primary analysis timing cutoff.
- Open-label (OL) Treatment: Participants with 24-week CDP as assessed by EDSS are eligible for 2-year open-label orelabrutinib treatment.
- Safety Follow-Up Period: It will last 4 weeks. The safety follow-up period will begin when the participants discontinue from the treatment before the end of the trial for any reasons or complete the trial but do not enter the long-term safety study (LTS) (see below).
All active study participants will have a final end of study (EOS) visit within 4 weeks of the study end date. Participants who are receiving IMP in DB or OL but do not consent to or are not eligible for enrollment in the LTS study, must return for a final safety follow-up visit 4 weeks later. For participants who intend and are eligible to join the LTS, open-label treatment with orelabrutinib will continue and no safety follow-up will occur.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 to 60 years of age, inclusive, at the time of signing the informed consent.
- •Participant must have a previous diagnosis of RRMS in accordance with 2024 McDonald criteria
- •Participant must have a current diagnosis of SPMS in accordance with the clinical course criteria revised in 2013
- •Participant must have documented evidence of disability progression independent of clinical relapse observed during the 24 months before screening. A written summary of the clinical evidence of disability progression must be discussed and aligned between the Investigator and the Sponsor's dedicated qualified person(s).
- •Absence of clinical relapses for at least 24 months.
排除标准
- •The patient has been diagnosed with primary progressive MS (PPMS) according to 2024 McDonald diagnostic criteria
- •Immunologic disorder other than MS or any other conditions requiring corticosteroid therapy.
- •History or current diagnosis of other neurological disorders that may mimic MS
- •History or current diagnosis of progressive multifocal leukoencephalopathy
- •Active, clinically significant viral, bacterial, or fungal infection
- •History of any other significant active medical condition
- •History of suicidal behavior within 6 months prior to Screening
- •Any prior history of malignancy
- •Patients on anticoagulation, or antiplatelet therapy
- •Patients took strong/moderate CYP3A inhibitors or strong/moderate CYP3A inducers within 14 days
- •Clinically significant laboratory abnormalities at Screening.
- •Vaccination with live or live-attenuated virus vaccine within 1 month prior to Screening
- •History of alcohol abuse or alcohol use disorder or other drug abuse within 12 months prior to screening.
研究组 & 干预措施
Placebo Group
Placebo PO daily
干预措施: Placebo (Drug)
Orelabrutinib Group
Orelabrutinib PO daily
干预措施: Orelabrutinib (Drug)
结局指标
主要结局
Time to onset of confirmed disability progression (CDP) events, confirmed over at least 24 weeks
时间窗: Up to approximately 120 weeks
Expanded disability status scale (EDSS) score increase ≥ 1.0 point from baseline when the baseline score is ≤ 5.0, or ≥ 0.5 points from baseline when the baseline score is \> 5.0
次要结局
- 12 Week CDP(Up to approximately 120 weeks)
- T2 lesions on MRI(Up to approximately 120 weeks)
- 24-week CDP-9-hole Peg Test(Up to approximately 120 weeks)
- 24-week CDP-T25FWT(Up to approximately 120 weeks)
- 24-week CDI-9HPT(Up to approximately 120 weeks)
- 24-week CDI(Up to approximately 120 weeks)
- 24-week CDI-T25FWT(Up to approximately 120 weeks)
- Symbol Digit Modalities Test(Up to approximately 120 weeks)
- Annualized relapse rate(Up to approximately 120 weeks)
- To evaluate the safety and tolerability of orelabrutinib(Up to approximately 120 weeks)