Evaluation of the Effect of Mediterranean Diet on Body Composition, Oxidant Stress and Proinflammatory Markers in Breast Cancer Patients
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Breast Cancer
- 发起方
- Aydin Adnan Menderes University
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Change in resting metabolic rate (RMR) measured by bioelectrical impedance analyzer
- 状态
- 已完成
- 最后更新
- 5年前
概览
简要总结
In this study, it was aimed to evaluate the effect of the Mediterranean diet on body composition, oxidant stress and proinflammatory markers in overweight and obese breast cancer women.
详细描述
Breast cancer is the most common type of cancer among women in both developed and developing countries and is the leading cause of cancer death among women worldwide. Breast cancer is a disease that can develop and progress for various reasons. In addition to unchangeable factors such as increasing age and genotype, modifiable factors such as smoking, alcohol consumption, lack of physical activity, malnutrition, and obesity play a role in the pathogenesis of the disease. Breast cancer risk increases with increasing body mass index (BMI) in postmenopausal women. Chronic inflammation in obesity is associated with an increase in the release of proinflammatory factors (such as TNF-α, IL-1, IL-6). This situation; It is a risk factor for many types of cancer such as colon, stomach, breast and prostate carcinomas and supports a cause-effect relationship between obesity and cancer. These proinflammatory factors act as signal converters for tumor growth and progression. Obese women have elevated levels of TNF-α and IL-6 in the circulation, and this is associated with the development and progression of breast tumors. The Mediterranean Diet, which consists of high amounts of monounsaturated fatty acids, fruits, vegetables and whole grains, has been widely evaluated and indicated as an important factor in preventing tumor formation from inflammatory pathways. Weight loss improves the antitumor immune system, lowers estrogen levels, reduces the risk of breast cancer and has been associated with better outcomes in obese patients. Lifestyle intervention studies strongly suggest that weight loss is possible and observational studies can actually improve breast cancer survival.In this regard, a healthy lifestyle and diet are the first steps to prevent breast cancer.
研究者
Burcu Deniz Gunes
Research Assistant
Aydin Adnan Menderes University
入排标准
入选标准
- •At least 18 years old,
- •BMI value to be ≥25 kg/m2,
- •To be diagnosed with breast cancer stage I, II or III,
- •Being a positive hormone receptor status, one of the biological subtypes of breast cancer,
- •Having completed chemotherapy and / or radiotherapy treatment at least 6 months before starting the study,
- •Not applying any treatment for body weight loss,
- •Accepting to participate in the study,
- •Perceiving disorder and not having communication problems.
排除标准
- •Being under the age of 18 and over the age of 65,
- •BMI value to be 40 kg/m2,
- •Having advanced stage breast cancer (IV and V),
- •Being diagnosed with cancer or metastasis in other organs,
- •Being one of the biological subtypes of breast cancer, hormone receptor status being negative,
- •Using antioxidant vitamin-mineral supplements,
- •Using herbal supplements,
- •Being pregnant or planning a pregnancy,
- •To stop working after starting diet therapy.
结局指标
主要结局
Change in resting metabolic rate (RMR) measured by bioelectrical impedance analyzer
时间窗: Baseline, 8 weeks
RMR (kcal) was measured using the InBody 270 brand device.
Change in interleukin 6 (IL-6)
时间窗: Baseline, 8 weeks
Blood was drawn from participants for assessment of IL-6 (pg/mL) at the beginning and end of the study after fasting for at least 8 hours
Change in total antioxidant status (TAS)
时间窗: Baseline, 8 weeks
Blood was drawn from participants for assessment of TAS (mmol/L) at the beginning and end of the study after fasting for at least 8 hours
Change in fat-free mass measured by bioelectrical impedance analyzer
时间窗: Baseline, 8 weeks
Fat-free mass (kg) was measured using the InBody 270 brand device.
Change in malondialdehyde (MDA)
时间窗: Baseline, 8 weeks
Blood was drawn from participants for assessment of MDA (mmol/L) at the beginning and end of the study after fasting for at least 8 hours
Change in body weight
时间窗: Baseline, 8 weeks
Body weight (kg) was measured using the InBody 270 brand device.
Change in body mass indexs
时间窗: Baseline, 8 weeks
The BMI is defined as the body mass divided by the square of the body height, and is expressed in units of kg/m\^2, resulting from mass in kilograms and height in metres.
Change in tumor necrosis factor alpha (TNF-α)
时间窗: Baseline, 8 weeks
Blood was drawn from participants for assessment of TNF-α (pg/mL) at the beginning and end of the study after fasting for at least 8 hours
Change in total oxidant status (TOS)
时间窗: Baseline, 8 weeks
Blood was drawn from participants for assessment of TOS (µmol/L) at the beginning and end of the study after fasting for at least 8 hours
Change in fat mass measured by bioelectrical impedance analyzer
时间窗: Baseline, 8 weeks
Fat mass (kg) was measured using the InBody 270 brand device.
次要结局
- Change in oxidative stress index (OSI)(Baseline, 8 weeks)
- Change in waist circumference(Baseline, 8 weeks)
- Change in hip circumference(Baseline, 8 weeks)
- Change in dietary inflammatory index (DII)(Baseline, 8 weeks)