Amino acids and / or multiple Micronutrients in Adult Zambians with environmental Enteropathy: effects on intestinal structure & function and host-microbiome interactions. A randomised placebo controlled trial.

Queen Mary University of London0 个研究点目标入组 128 人开始时间: 2015年4月16日最近更新: 2023年5月29日

试验速览

暂无简介。

•Intervention arms (environmental enteropathy participants):
•Age between 18 and 60 years
•Resident in B section, Misisi compound
•Able to give informed consent
•Unaffected control group:
•Age between 18 and 60 years
•Able to give informed consent
•Household has running water, plumbed indoor toilet and electricity
•Household owns a vehicle and television
•In full-time education or full-time employment
•Resident in Woodlands, Kabulonga, Leopard¿s Hill, Ibex Hill, Longacres, Kalundu or other affluent suburb
•Already referred for diagnostic upper GI endoscopy indicated as part of standard clinical care

•Pregnancy (by self-report)
•Breast feeding (by self-report)
•Antibiotic use within previous 4 weeks
•Regular NSAID use within previous 4 weeks
•Diarrhoea within previous 4 weeks
•Significant comorbidity precluding endoscopy with sedation
•Therapeutic anticoagulation or bleeding diathesis precluding endoscopic biopsies
•Unwilling to undergo HIV testing
•Untreated helminth infection
•Unwilling to consent to long-term storage of samples

发起方