Vascular Reparative Mechanism by ACE2/Ang-(1-7) in Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 78
- 试验地点
- 1
- 主要终点
- The ACE/ACE2 ratio within EPC's
研究概览
简要总结
The purpose of this research study is to study blood stem cells in diabetic patients and normal patients. We would like to better understand if these cells, called endothelial precursor cells (EPCs), are not working as expected in people with diabetes. We would like to see if the function of these cells can predict the development of diabetic retinopathy.
Diabetic retinopathy is an eye disease associated with diabetes in which the cells of the retina are damaged. It can cause blurred vision, vision loss, blindness or possible bleeding in the retina. Even with current treatments, the quality of life for people with diabetic retinopathy is much reduced.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men or women 18 years or older
- •39 type 1 or type 2 diabetic patients
- •13 with mild retinopathy
- •13 with moderate retinopathy
- •13 with severe, nonproliferative retinopathy
- •39 age and sex matched healthy controls
排除标准
- •Current pregnancy as evidence by a urine pregnancy test as the blood from a pregnant female will influence the results of the laboratory tests
结局指标
主要结局
The ACE/ACE2 ratio within EPC's
时间窗: up to 216 weeks
Peripheral blood of 150cc, approximately 8-10 tablespoons will be collected from a vein in the arm of both diabetic and healthy control patients.
次要结局
- The balance of the RAS (renin-angiotensin system) within EPCs(up to 216 weeks)
研究者
Maria Grant
Professor
University of Alabama at Birmingham