A Global Approach to Tackle Cognitive Decline
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 1,502
- 试验地点
- 1
- 主要终点
- Record of any vascular risk factors
研究概览
简要总结
The number of people suffering from dementia in Asia (22.9 million) is more than twice the numbers in Europe (10.5 million) or the Americas (9.4 million), as recorded in the global impact of dementia in the World Alzheimer Report 2015.1 This dementia tsunami will continue to rise and the estimated number is 67 million in 2050 in Asia alone, which will be 2 to 3 times higher than the estimates for Europe (19 million) or the Americas (30 million). Devising and implementing preventive strategies against dementia is of paramount importance. The proposed project will be able to establish the associations between VRFs and cognition across cohorts with cultural, ethnical, and demographical variations. This study will generate data for evidence-based knowledge for globally implementable and effective preventive strategies for cognitive impairment and dementia.
详细描述
Participants will be retrospectively selected from a Hong Kong Chinese cohort, a Singaporean cohort, a British cohort, two European cohorts, and an Australian cohort.
Subjects from the above listed cohorts who fit the study criteria will be selected for this study.
Demographical information, clinical, vascular risk factors, MRI images and cognitive data will be retrieved from the cohorts.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Elderly community-dwelling individuals aged over 60 years old;
- •those with at least 2 time points of detailed cognitive measurements, with 2-3 years of assessment interval;
- •with at least 1 timepoint of MRI (T1, FLAIR, and DTI).
排除标准
- •subjects with stroke, dementia, and other neurological diseases at baseline;
- •those without longitudinal cognitive data;
- •those without MRI data available.
结局指标
主要结局
Record of any vascular risk factors
时间窗: Baseline
medical history of hypertension, diabetes mellitus, hyperlipidemia, smoking and drinking, record unit as yes or no
Record of low-density-lipoprotein level,
时间窗: Baseline
low-density-lipoprotein level, as one of the vascular risk factors, unit as mmol/L
Record of total cholesterol level,
时间窗: Baseline
total cholesterol level, as one of the vascular risk factors, unit as mmol/L
Record of pulse
时间窗: Baseline
Pulse rate, as one of vascular risk factors, unit as bpm
Record of triglyceride level
时间窗: Baseline
triglyceride level, as one of vascular risk factors, unit as mmol/L
Record of high-density-lipoprotein level,
时间窗: Baseline
high-density-lipoprotein level, as one of the vascular risk factors, unit as mmol/L
Record of fasting blood glucose
时间窗: Baseline
fasting blood glucose from blood results, as one of vascular risk factors, unit as mmol/L
Record of glycated hemoglobin
时间窗: Baseline
glycated hemoglobin, as one of the vascular risk factors, unit as percentage
Change of Montreal Cognitive Assessment
时间窗: Baseline, 1 yr, 2yr and 3rd year follow ups
Montreal Cognitive Assessment is used for measuring general cognition including the domains of attention and processing speed, executive function, memory, visuospatial function, and animal fluency.
Changes of brain white matter abnormalities
时间窗: Baseline and 1 yr, 2yr and 3rd year follow ups
brain white matter abnormalities can be observed through the FLAIR sequence of brain MRI images
Record of blood pressure
时间窗: Baseline
Blood pressure, as one of vascular risk factors, unit as mmHg
Change of Mini-Mental State Examination
时间窗: Baseline and 3rd year follow up
Mini-Mental State Examination is used for measuring general cognition including the domains of attention and processing speed, executive function, memory, visuospatial function, and animal fluency.
次要结局
未报告次要终点
研究者
Bonnie Yin Ka LAM
Research Assistant Professor
Chinese University of Hong Kong