The Correlation of the Lower Placental Edge Thickness in Relation to Gestational Age at Delivery by Using Ultrasonography in Patients With Placenta Previa Accreta; A Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Lower placental edge thickness measurements by ultrasound in patients having placenta previa accreta.
研究概览
简要总结
The aim of our study is to determine correlation between lower placental edge thickness measured by ultrasound and gestational age at delivery and predict the risk of emergency preterm birth in patients having placenta previa accreta.
详细描述
In pregnant women with placenta previa accreta, the lower placental edge thickness measured by ultrasound may correlate with gestational age at delivery and predict emergency preterm cesarean delivery. Thick lower placental edge is thought to be responsible for emergency preterm birth.
All women who meet the inclusion criteria will undergo full assessment to identify eligible women.
This assessment will include:
Detailed History:Personal history: age, duration of marriage, smoking. Present history: any current medical or surgical diseases and current medication.
Past medical history: history of medical disorders like diabetes and hypertension.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Single, viable gestations. Gestational age >28 weeks, < 36 weeks.
- •Confirmed diagnosis of placenta previa accreta when the placenta lies directly over the internal os based on ultrasound features among RCOG criteria as follows) RCOG,2019):
- •2D greyscale signs: loss of myometrial interface or retroplacental clear space, reduced myometrial thickness, intra-placental blood flow and intra-placental lacunae.
- •2D color Doppler signs: intra-placental blood flow, the presence of altered blood flow in the retroplacental space and aberrant vessels crossing between placental surfaces.
- •First time of diagnosis of placenta previa accreta is 28-30 weeks. Previous one or more cesarean sections.
排除标准
- •Maternal medical co-morbidities like diabetes and hypertension. Patients with bleeding disorders or anticoagulant therapy. Over distended uterus e.g.: multiple gestation, polyhydramnios, fetal macrosomia(>4.5kg).
- •Fetal anomalies or fetal growth restriction. Emergency cesarean section due to fetal distress. Rupture of membranes, intra-amniotic infection and fever during admission (>38 °C).
- •History of cervical cerclage or cervical cone biopsy.
结局指标
主要结局
Lower placental edge thickness measurements by ultrasound in patients having placenta previa accreta.
时间窗: Baseline
Lower placental edge thickness measurements by ultrasound in patients having placenta previa accreta until delivery will occur.
次要结局
- Neonatal birth weight.(Baseline)
- Gestational age at delivery.(Baseline)
- Peripartum blood transfusion(Baseline)
- Need for Cesarean hysterectomy(Baseline)
- Type of cesarean delivery(Baseline)
- Antepartum bleeding, post-partum hemorrhage .(Baseline)