Intensive Glycemic Control for Congestive Heart Failure Exacerbation
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 74
- 试验地点
- 1
- 主要终点
- Hospital Length of Stay
研究概览
简要总结
Patients with heart failure often have high blood sugar (glucose).
详细描述
Patients with heart failure often have high blood sugar. High glucose contributes to severe hospital complications and even death. Studies suggest that heart failure patients who have high glucose or diabetes do not live as long as patients with normal glucose. In this study, we will determine whether normalizing blood sugars using intravenous insulin short-term will improve outcomes in patients hospitalized for congestive heart failure. We enrolled patients with severe heart failure and randomly assigned them into 2 groups. We used intravenous (given through the vein) insulin to lower blood sugar levels in group 1, and insulin injections in group 2. We determined whether intravenous insulin improved hospital length of stay, rates of readmission, inflammatory markers, and cardiovascular tests that predict mortality in patients with heart failure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 and above
- •Admitted (less than 48 hours) to the OSU Ross Heart Hospital with worsening heart failure
- •Hyperglycemia or diabetes. Hyperglycemia is defined as blood glucose greater than 150 mg/dL on at least 2 occasions separated by at least 4 hours apart, insulin use, or HbA1c >6.5%.
排除标准
- •Type 1 diabetes
- •Receiving comfort care measures only
- •Hospital stay expected to be less than 2 days
- •Pregnancy
- •Prisoners
- •Participation in the study on prior hospitalizations
- •Acute myocardial infarction within 3 months
- •End stage renal or liver disease
研究组 & 干预措施
Subcutaneous Insulin
Basal bolus insulin (4 injections per day)
干预措施: Subcutaneous insulin (Drug)
Intravenous Insulin
干预措施: Intravenous insulin (Drug)
结局指标
主要结局
Hospital Length of Stay
时间窗: Days
Duration of hospitalization in days
次要结局
- Hospital Readmission(30 days)
- Change in Quality of Life(30 day)
- Brain Natriuretic Peptide (BNP)(72 hours)
- Heart Rate Variability(72 hours)
- Cardiac Output(72 hours)
研究者
Kathleen Dungan
Assistant Professor
Ohio State University