Addictions Neuroclinical Assessment
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 1,400
- 试验地点
- 1
- 主要终点
- To examine the relationship between the three ANA domains (i.e. Negative Emotionality, Incentive Salience, Executive Function).
研究概览
简要总结
Background:
Alcohol use disorder (AUD) is a major public health problem. In the U.S., 16 to 18 million adults have an AUD. Researchers want to test an assessment tool called the ANA. It uses self-report and behavioral measures to assess 3 neuroscience domains of addiction. They hope to better understand, manage, prevent, and treat AUD.
Objective:
To learn how people s brains function related to their drinking.
Eligibility:
People ages 18 years and older who have enrolled in NIAAA natural history study 14-AA-0181.
Design:
Participants will complete surveys and tasks on a computer. The surveys and tasks assess a range of aspects of thinking and making decisions. The surveys and tasks also assess behaviors and feelings about alcohol and other rewards, and negative emotions. Participants will spend 90 minutes on the computer. Then they will take a break. In total, they will spend 4 blocks of time on the computer. Each block will last 90 minutes. They will take a break in between each block of time. They can take more breaks if needed.
Outpatient participants and healthy volunteers will complete this study in 1 visit. It will last about 6 hours. A second visit may be scheduled if needed. Outpatient participants will take a breath alcohol test. If their test is positive, their visit may be rescheduled or they may be withdrawn from the study.
Inpatient participants will complete this study over several days.
Data collected from participants in this study may be combined and analyzed with their data from NIAAA study 14-AA-0181 and/or NIAAA imaging study 14-AA-0080....
详细描述
Study Description:
This is a protocol examining a battery of assessments designed to study three neurofunctional domains relevant to alcohol use disorder (AUD), negative emotionality, incentive salience and executive function. The study will examine the relationships among the three ANA domains with the goal of identifying sub-types of AUD based on variation in the ANA domains.
Objectives:
Primary Objectives:
- To examine the relationship between the three ANA domains
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •INCLUSION CRITERIA:
- •In order to be eligible to participate in this study, an individual must meet both of the following criteria:
- •Participants must be > 18 years of age
- •Participants must have enrolled in the NIAAA Screening Protocol (14-AA-0181).
排除标准
- •There are no formal exclusionary criteria for this study. Based on enrollment criteria for the NIAAA Screening Protocol, individuals less than 18 years of age, or prisoners will not be enrolled in this study.
- •Outpatients will be tested for acute intoxication/impairment at the time of consent and study procedures using an alcohol breathalyzer and a clinical evaluation. Individuals with a positive breath alcohol concentration (BrAC), or those who are determined to be acutely intoxicated or impaired by the clinicians will be re-scheduled or withdrawn from the study.
- •In addition, individuals who are determined by the clinicians to be uncooperative or unable to provide consent, will not be invited to participate in this study. Individuals who report not being able to use a mouse and keyboard, or who are determined by the clinical research team to be unable to use a mouse and keyboard, will not be invited to participate in this study.
研究组 & 干预措施
non-treatment-seeking individuals
Participants across the spectrum of drinking (from non-drinkers to heavy drinkers) who are not interested in treatment for alcohol use disorder
treatment-seeking individuals with alcohol use disorder
Volunteers with an AUD diagnosis who are seeking treatment for the condition
结局指标
主要结局
To examine the relationship between the three ANA domains (i.e. Negative Emotionality, Incentive Salience, Executive Function).
时间窗: 1 visit
Once the latent factors associated with each of the three ANA domains are identified, structural relationships between the latent factors can be modeled and described.
To identify the different subtypes of AUD based on variation in the ANA domains.
时间窗: 1 visit
Additionally, once the latent factors are identified, they can be used to categorize individuals into latent groups (AUD subtypes) based on the variation of their scores on each of the domains.
次要结局
未报告次要终点