Heart Failure With Preserved Ejection Fraction and Its Cardiac MR Characteristics of Different Subtypes
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Rate of Cardiovascular death
研究概览
简要总结
Using cardiac magnetic resonance imaging technology, the ejection fraction of heart failure (HFpEF) and different subtypes of cardiac magnetic resonance characteristics, and combined with the clinical characteristics and prognosis of the patient, explore the value of cardiac magnetic resonance in disease diagnosis, classification, treatment and prognosis, and provide new ideas for clinical practice.
详细描述
- Study Objectives To compare clinical characteristics among HFpEF patients with different comorbidity subtypes (hypertension, type 2 diabetes, renal insufficiency, obesity).
To identify distinct cardiac magnetic resonance (CMR) features associated with HFpEF and its comorbidity subtypes.
To evaluate prognostic differences (mortality, heart failure readmission, healthcare costs) across HFpEF subtypes. 2. Study Design Type: Single-center, prospective, observational cohort study. Duration: April 1, 2023 - December 31, 2026. Sample Size: 500 HFpEF patients, with ~200 patients per subgroup. 3. Data Collection Framework
Baseline Data:
Clinical Parameters:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age is 50 years old.
- •Cardiac color ultrasound shows an ejection fraction (EF) of 50% or more.
- •Symptoms / signs of heart failure and increased natriuretic peptide levels during hospitalization / visit (BNP 100 pg/mL or NT-proBNP 400 pg / mL).
排除标准
- •Severe liver and kidney insufficiency
- •Severe valvular heart disease (severe, severe severe) or known infiltrative or hypertrophic cardiomyopathy
- •Malignant tumors and severe hematological diseases
- •severe infection
- •Autoimmune system diseases
结局指标
主要结局
Rate of Cardiovascular death
时间窗: follow - up every 6 months; up to 24 - months
Rate of readmission of heart failure
时间窗: follow - up every 6 months; up to 24 - months
次要结局
- Body Temperature(Baseline)
- Blood Glucose Levels(Baseline)
- Brain Natriuretic Peptide (BNP)(Baseline)
- Glycated Hemoglobin (HbA1c)(Baseline)
- Blood Pressure(Baseline)
- Heart Rate(Baseline)