ISRCTN04337637已完成不适用
Subclinical Hyperthyroidism 'To Treat or Not to Treat?' - A Dutch Multicentre Trial
niversity Medical Centre St Radboud (Netherlands)0 个研究点目标入组 192 人开始时间: 2005年9月12日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 192
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Subclinical hyperthyroidism [TSH <= 0.1 mU/L, fT4 and T3 within the normal range of the own laboratory (determined 2 times in own laboratory with an interval of at
- •least 2 months)
- •2. Endogenous cause of subclinical hyperthyroidism limited to autonomous adenoma or multinodular goiter (diagnosis made by the attending physician, based on palpation and the result of a thyroid scintigram)
- •3. Informed consent
排除标准
- •1. Medication with anti-thyroid drugs in the last 3 months (also not allowed during follow-up), thyroid hormone in the last 3 months (allowed during follow-up, but TSH levels should be kept between 0.1 mU/L and the upper limit of normal in the own laboratory) and oral glucocorticoids in the last 3 months (allowed during follow-up when absolutely necessary, but patients in whom glucocorticoids are
- •started cannot be evaluated with respect to changes in BMD).
- •2. Radioiodine therapy in the past
- •3. Iodine-induced subclinical hyperthyroidism
- •4. Pituitary or hypothalamic insufficiency
- •5. Pregnancy
- •6. Age <= 50 years and > 80 years
- •7. Severe non-thyroidal illness
- •8. Drug abuse
- •9. Unstable angina pectoris, (history of) atrial fibrillation, (history of) congestive heart failure.
- •10. (History of) osteoporotic fracture(s)
- •11. Patients younger than 70 years of age with a bone mineral density T-score <2.5
- •SD, or older than 70 years of age with a bone mineral density Z-score <-1.0 SD
- •12. These patients can be randomised but in case it is decided to treat them with antiosteoporotic drugs they cannot be evaluated with respect to changes in BMD.
- •13. Use of betablockers in the last three months. These patients can be randomised but cannot be evaluated with respect to
- •general and cardiac symptoms. The same applies to patients in whom betablockers are started during follow up.
- •14. Other symptoms or signs of hyperthyroidism or obstruction of vital structures which in the opinion of the attending physician urge to active treatment.
研究者
相似试验
招募中
不适用
Subclinical Hyperthyroidism To Treat or Not to Treat? A Dutch Multicenter Trial.NL-OMON21676192
Unknown
不适用
Does Radioiodine Treatment Prevent Atrial Fibrillation and Bone Loss in Endogenous Subclinical Hyperthyroidism?HyperthyroidismNCT00151723Radboud University Medical Center200
进行中（未招募）
Unknown
Exploring symptoms and signs of mild thyroid overactivity in Dutch primary careSubclinical hyperthyroidismNutritional, Metabolic, EndocrineISRCTN15496928Amsterdam University Medical Centers200
尚未招募
2 期
To develop a unani medicine for the treatment of subclinical hypothyroidismCTRI/2021/06/034158Ayurvedic and Unani Tibbia College and Hospital
进行中（未招募）
不适用
HoT – A phase III randomised trial to compare the rates of cancer returning in patients with low-risk differentiated thyroid cancer after a hemithyroidectomy and total thyroidectomyCancerISRCTN17004671niversity College London456