Memory Training Versus Yogic Meditation Training in Older Adults With Mild Cognitive Impairment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 81
- 试验地点
- 2
- 主要终点
- Cognitive Measures - Hopkins Verbal Learning Test (HVLT) Total Recall Score
研究概览
简要总结
The purpose of this pilot study is to test whether 6 months of supervised weekly Kundalini yoga classes and a brief daily meditation homework assignment can improve memory and thinking in older adults with mild memory complaints when compared to weekly classes of memory training with daily homework assignments.
详细描述
The purpose of this pilot study intervention is to investigate brain mechanisms of response to memory enhancement training (MET) compared to Kundalini yoga and "Kirtan Kriya" meditation using functional magnetic resonance imaging (fMRI) that will be acquired from each subject at baseline and at 12 weeks (post-randomization).
Overall, the investigators anticipate recruiting 66 adults with memory complaints and diagnosed with MCI for adults 55 years old and older. Subjects will either receive: (1) MET class for 60 minutes per week; or (2) Kundalini yoga and "Kirtan Kriya" meditation class for 60 minutes per week. All assessments will be completed immediately after the interventions for a total of 10 visits in 12 weeks and a follow-up visit at 6 months (24 weeks)to monitor the overall benefit of the intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 55 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Mild cognitive impairment amnestic type
- •Clinical Dementia Rating scale score of 0.5
- •SufficientEnglish proficiency and 8th grade or higher reading level as determined by the word reading subtest of the Wide Range Achievement Test-IV
- •Capacity to provide informed consent.
排除标准
- •Any current or past psychiatric disorders, or recent unstable medical or neurological disorders
- •Any disabilities preventing their participation in the memory enhancement training (MET) (e.g. severe visual or hearing impairment)
- •Insufficient English proficiency
- •Diagnosis of dementia
- •Mini Mental Health Examination score of 24 and below
- •Psychoactive medications
- •Participation in a psychotherapy that involves cognitive training
- •Do not meet criteria for Mild cognitive impairment subtype
- •Prior or current training in yoga.
研究组 & 干预措施
Memory Training
Group memory training will be administered for amnestic mild cognitive impairment (MCI)
干预措施: Memory Training (Behavioral)
Kundalini yoga and meditation
Participants will engage in weekly yoga classes and daily 20 minute meditation
干预措施: Kundalini yoga and meditation (Behavioral)
结局指标
主要结局
Cognitive Measures - Hopkins Verbal Learning Test (HVLT) Total Recall Score
时间窗: At baseline and at 6 months
Primary outcome measures were administered by a cognitive battery of neuropsychological and included memory and executive functioning. Verbal memory was measured with the Hopkins Verbal Learning Test (HVLT) total recall scores. The HVLT form contains 12 nouns, four words each from one of three semantic categories (e.g., precious gems, articles of clothing, vegetables, etc.), to be learned over the course of three learning trials. When scoring the HVLT, the three learning trials are combined to calculate a total recall score. Total scores range from 0-36 with higher scores indicating better outcome.
次要结局
- Geriatric Depression Scale (GDS)(Baseline and Week 24)
- Change in Functional Magnetic Resonance Imaging (fMRI) Connectivity(12 weeks)
- Clinical Global Impression Scale(Baseline, weeks 2, 4, 6, 8, 10, 12, 24)
研究者
Helen Lavretsky, MD
Professor
University of California, Los Angeles