Sciatic Nerve Block for Ankle/Foot Surgeries. A Comparison Between a Premixed Solution of Lidocaine Plus Bupivacaine and Consecutive Infiltration of Lidocaine and Bupivacaine. A Double Blinded Randomised Controlled Prospective Study
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Postoperative analgesia/duration of block
研究概览
简要总结
Regional anaesthesia has become the cornerstone of multimodal analgesia. With the advent of ultrasound guided nerve blocks regional anaesthesia has achieved both greater efficacy and a better safety profile as the injection of local anaesthetic is performed under direct vision. This has allowed a reduction of the amount of local anaesthetic injected as compared to peripheral nerve stimulation technique . Blockade of sciatic nerve combined with saphenous nerve provides anaesthesia and analgesia for ankle/foot surgeries. Various combinations of local anaesthetics have been used to provide optimal blockade . A mixture of lidocaine with a long acting local anaesthetic is commonly used. This provides a rapid onset of blockade, but of a consistently shorter duration compared to a long acting local anaesthetic alone. We hypothesize that sequential perineural injection of lidocaine and bupivacaine provides similar onset but a longer duration of sensory block compared to the same dose and volume of local anaesthetic mixed in advance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with ASA 1 - 3 status
- •scheduled to undergo semi-elective ankle/foot surgery under regional anaesthesia +/- sedation/opioid free general anaesthesia will be recruited
排除标准
- •Patients having surgery on the medial aspect of the ankle/ foot
- •allergy to local anaesthetics
- •coagulopathy
- •malignancy or infection in the popliteal area
- •significant peripheral neuropathy
- •neurologic disorder of the lower extremity
- •any other contraindication to sciatic nerve block
- •pregnancy
- •history of alcohol or drug dependency/abuse (defined as >40 IU/week)
- •a history of significant cognitive or psychiatric disorder that may affect patient assessment
研究组 & 干预措施
Premixed group
Patients will receive sciatic nerve block with premixed 7.5 mls of 2% lidocaine/adrenaline and 7.5 mls of 0.5% bupivacaine followed by an interval of 90 seconds with an injection of same amount of both drugs.
干预措施: 2% lidocaine/adrenaline and 0.5% bupivacaine (Drug)
Sequential Group
Patients will receive a sciatic nerve block with 15 mls of 2% lidocaine/adrenaline followed by an interval of 90 seconds with 15 mls of 0.5% bupivacaine.
干预措施: 2% lidocaine/adrenaline and 0.5% bupivacaine (Drug)
结局指标
主要结局
Postoperative analgesia/duration of block
时间窗: 24 hours
次要结局
- onset of block(40 minutes)
研究者
DR. Jassim Rauf
Clinical Research/ Peripheral Nerve Blocks Fellow.
Cork University Hospital
