NCT01221766已完成不适用
The Impact of Adnexal Involvement of the Severity and Prognosis of Chronic Graft-versus-Host Disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Adnexal involvement
研究概览
简要总结
This research study will help us learn more about how chronic graft-versus-host disease affects the skin, hair and nails. We are interested in knowing if hair and nail problems predict worse disease. This information may help us treat patients like you in the future.
详细描述
- At the initial visit, participants will have a complete examination of their skin, hair and nails. We will also test muscle strength and movement by moving the participant's arms, legs and neck. Photographs will be taken of the skin, hair and nails of they are abnormal. Blood tests will be done to check the liver and blood cell count. The participant and their legal guardian will answer questions about how the participant feels and about their health.
- Participants will then be scheduled for follow up visits at 3 months, 6 months, and 12 months. At each subsequent visit the following will be done: A complete examination of the skin, hair and nails; a test of muscle strength; photographs will be repeated; blood tests to check liver and blood cell counts; and questions about how the participant feels and about their health.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Received hematopoietic stem cell transplant
- •Meet the diagnostic criteria for cutaneous cGVHD
排除标准
- •Previous HSCT (other then the current HSCT)
结局指标
主要结局
Adnexal involvement
时间窗: 1 year
To determine if adnexal involvement predicts worse severity and/or prognosis in chronic GVHD. This will be measured by administration of systemic therapy other than steroids.
次要结局
未报告次要终点
研究者
Jennifer Huang, MD
Instructor in Dermatology
Dana-Farber Cancer Institute
研究点 (2)
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