Differences in serotonin synthesis between patients with major depression and healthy controls, measured with [11C]5-HTP PET - Serotonin synthesis in depression

niversitair Medisch Centrum Groningen0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•- Out-patients
•- Age 18-55.
•- Major depressive disorder, single or recurrent episode according to DSM IV.
•- Severity: >22 IDS-SR
•- No psychotic features
•- No intention to commit suicide, or a history of a seroious suicide attempt
•- No proven non-response to CBT during the current or a previous episode
•- No current or recent (< 3 months) alcohol or substance use disorder (smoking is allowed).
•- Declared somatically healthy after medical examination.
•- No current or recent (<1 month) pharmacological treatment (antidepressant, antipsychotic, lithium, anticonvulsant, benzodiazepine)
•- Understanding Dutch language and judged capable to participate
•- Willing to cooperate and sign the informed consent form.;Healthy volunteers
•- Matched for gender and age
•- Age 18-55.
•- No lifetime major psychiatric disorders (e.g. psychosis, mood disorder, anxiety disorder, somatoform disorder, eating disorder)
•- No lifetime treatment with an antidepressant, antipsychotic, lithium or anticonvulsant
•- No long-term treatment (>1 month) and no current (<1 month) with a benzodiazepine
•- No current or recent (< 3 months) alcohol or substance abuse and no lifetime alcohol or substance dependence (smoking is allowed)
•- Declared somatically healthy after medical examination.
•- Willing to cooperate and sign the informed consent form.

•Similar for patients and healthy controls
•- Indication of medical/somatic illness that could interfere with study results or constitutes a risk factor when participating in the study and undergoing treatment.
•- Cardiovascular abnormalities that may be a risk factor when participating in the study.
•- Neurological damage or previous severe head injury
•- Consumption of chocolate, caffeinated products or tabacco within 24 hours of the scan.
•- Pregnancy or the intention to become pregnant during the estimated time course of the study.
•- Radiation exposure (for diagnostic reasons) as a radiological worker or during medical trial in the previous year.
•- Claustrophobia
•- Presence of materials in the body that can be magnetized, like:
•i. A pacemaker
•ii. Metal fragments
•iii. Shunts
•iv. Artificial heart valves
•v. Vascular clips
•vi. Fixed hearing aid
•vii. Tattoos containing metal
•viii. Hair implants
•ix. Artificial dentures

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