Comparison of Mg, Ketamine, Large Dose Rocuronium, and Priming on Intubating Condition in Rapid Sequence Intubation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- Intubation score
研究概览
简要总结
In this study, methods which are known for facilitating rapid sequence intubation or accelerating rocuronium (Roc)onset are compared including magnesium (Mg), ketamine pretreatment, large dose rocuronium and priming.
详细描述
Patients are pretreated with Mg, ketamine, or priming dose Roc. Two groups do not receive pretreatment, but are given Roc 0.6 mg/kg or 0.9 mg/kg.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 18 - 65 years,
- •ASA 1 - 2,
- •patients scheduled for elective surgery under general anesthesia,
- •BMI 18.5-24.9 kg/m2
- •Mallampati class I-II
排除标准
- •neuromuscular disorder,
- •cardiac/hepatic/renal insufficiency,
- •pregnant.
- •anticipated difficult airway
- •medications that influence neuromuscular transmission
研究组 & 干预措施
priming
Patients receive Roc 0.06 mg/ kg as a priming dose 3 min before injection of Roc 0.54 mg/kg.
干预措施: rocuronium (Drug)
ketamine
Patients receive ketamine 0.5 mg/kg 2 min before Roc injection.
干预措施: Ketamine (Drug)
Mg
Patients receive magnesium sulfate (MgSO4) 50 mg/kg over 10 min before Roc injection.
干预措施: Magnesium Sulfate (Drug)
结局指标
主要结局
Intubation score
时间窗: participants will be followed at the time point of intubation, an expected average of 70 sec from the start of rocuronium injection.
Patients are tracheally intubated, and intubation scores(poor, good,excellent)are rated.
次要结局
- Roc onset(participants will be followed when TOFcount =0 within an expected average of 4 min from the start of rocuronium injection.)
- Roc duration(participants will be followed when TOF count reaches two, an expected average of 40 min.)
- Hemodynamic variables(participants will be followed at baseline, before and for 5 min after the intubation, an expected average of 8 min after the start of anesthetic induction.)
- TOF% at intubation(participants will be followed at the time point of intubation, an expected average of 70 sec from the start of rocuronium injection.)
研究者
Kim Mihyun
clinical professor
Seoul National University Bundang Hospital