Algorithm for the Early Diagnosis and Treatment of Patients With Eosinophilia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 53
- 试验地点
- 2
- 主要终点
- Number of patients having correctly follow the diagnosis algorithm
研究概览
简要总结
Eosinophilia, defined by a blood eosinophil granulocytes rate greater than 500 / mm3, is frequently encountered in internal medicine.
Its causes are varied: atopy, drug allergies, parasitic infections, autoimmune diseases and solid neoplasias. Over 200 etiologies have been reported, some difficult to diagnose and can be life-threatening Eosinophilia can be a diagnostic dilemma, as the etiologies are extensive and varied.
The aim of this study is to assess the feasibility of a diagnostic approach based on a decision algorithm in a group of patients with eosinophilia.
We assume that a procedure with a hierarchy of additional tests would increase the frequency of diagnosed cases while decreasing the time to diagnosis.
This procedure defined by an algorithm would even reduce the number of tests necessary to reach a diagnosis.
详细描述
Eosinophilia, defined by a blood eosinophil granulocytes rate greater than 500 / mm3, is frequently encountered in internal medicine.
Its causes are varied: atopy, drug allergies, parasitic infections, autoimmune diseases and solid neoplasias. Over 200 etiologies have been reported, some difficult to diagnose and can be life-threatening
Eosinophilia can be a diagnostic dilemma, as the etiologies are extensive and varied.
The aim of this study is to assess the feasibility of a diagnostic approach based on a decision algorithm in a group of patients with eosinophilia.
The contribution to the diagnosis of a hierarchical strategy for prescribing additional tests , based on clinical examination as well as some simple diagnostic tests, has never been evaluated
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient having one of the three following criteria:
- •hypereosinophilia> 1500 / mm3, checked on at least two samples (interval between 2 samples at the discretion of the clinician)
- •or hypereosinophilia> 500 cells / mm3 and organ damage with infiltration NCB proven by pathological examination,
- •or hypereosinophilia> 500 cells / mm3 and found consistently for at least six months (present on all controls carried out before inclusion).
- •Patient affiliated or beneficiary of a social security system
- •Patient who signed the informed consent
排除标准
- •Patient with solid tumors known (under chemotherapy or planned)
- •Patient unable to understand or to adhere to the Protocol
- •Patient unable to give consent
- •Pregnant or breastfeeding women
- •Patient already participating in an interventional trial
研究组 & 干预措施
Algorithm
Eosinophilia is assessed following the diagnosis algorithm
干预措施: Scheduled exams and diagnosis (Other)
结局指标
主要结局
Number of patients having correctly follow the diagnosis algorithm
时间窗: 5 months
This outcome measure how many patients have correctly followed the diagnosis algorithm
次要结局
- Rate of diagnosis(5 months)
- Assess the time to diagnosis(5 months)
- Description of diagnosis(5 months)