Colchicine Use in Intracranial Atherosclerotic Disease - a Pilot Open-labelled Randomized Trial
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- Regression of intracranial stenosis
研究概览
简要总结
Intracranial atherosclerotic disease (ICAD) is a major ischaemic stroke aetiology in Asia. Influenced by genetics, lifestyle and metabolic risk factors. From the SAMMPRIS cohort, 1-year stroke recurrence risk was 13% even with intensive medical therapy.
In this pilot randomized, double-blind, placebo-controlled trial, the investigators shall recruit 44 patients with recent ischaemic stroke due to intracranial atherosclerosis (ICAD) with ≥ 50% stenosis. Patients will be randomly assigned to either low-dose colchicine (0.5mg daily) (n=22) or placebo (n=22) for 12 months. High-resolution magnetic resonance vessel wall imaging will be performed at baseline and 12 months. The primary endpoint is a composite of regression of intracranial stenosis, plaque volume, or occurrence of any major adverse cardio- or cerebrovascular events at 12 months. The investigators shall also evaluate safety endpoints including diarrhea, marrow suppression, infections, neuromuscular dysfunction.
No studies had focused on the use of colchicine in patients with ICAD, which is highly prevalent in Asia. Results from this pilot trial will provide an important basis for a larger-scale main trial in the future.
详细描述
Background:
Intracranial atherosclerotic disease (ICAD) is a major ischaemic stroke aetiology in Asia. Influenced by genetics, lifestyle and metabolic risk factors, over 40% of ischaemic strokes were related to ICAD in China. ICAD also predicted high risk of recurrence compared to other stroke aetiologies. From the SAMMPRIS cohort, 1-year stroke recurrence risk was 13% even with intensive medical therapy. While up-front endovascular intervention resulted in unacceptably high peri-procedural stroke risk of 20%-36%, minimal advances in medical therapy targeting ICAD had been made.
Literature clinical findings were supported by coronary plaque-imaging studies performed in human and animal models, which showed coronary plaque regression in patients with recent acute coronary syndrome and reduction in abdominal-aortic plaque inflammation in a rabbit-model. In parallel, under intensive medical therapy, ICAD plaque regression could be seen in 49% of patients. Nevertheless, recurrent stroke rate still exceeded 10% despite treatment targets of blood pressure ≤140/90, HbA1c ≤6.5%, and low-density lipoprotein (LDL) ≤1.8mmol/L in our previous cohort. There is a need to further reduce plaque growth, thrombogenicity and haemodynamic compromise by intensifying anti-atherosclerotic therapy. An updated meta-analysis showed that colchicine use in patients with high cardiovascular risk was associated with lower stroke incidence (12). However, no studies had focused on the use of colchicine in patients with ICAD, which is highly prevalent in Asia.
Objective:
In this pilot randomized, double-blind, placebo-controlled trial, the investigators aim to elucidate the efficacy and safety of low-dose colchicine (0.5mg daily) in patients with symptomatic intracranial atherosclerotic disease. The investigators hypothesize that low-dose colchicine in addition to intensive medical therapy, compared to intensive medical therapy alone, may result in more plaque regression in patients with symptomatic ICAD. Results from this pilot trial will provide an important basis for a larger-scale main trial in the future.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chinese patients aged 40-80 years old
- •Patients with symptomatic ICAD of ≥ 50% stenosis in middle cerebral arteries, basilar artery. Degree of stenosis will be quantified by computer tomographic angiography (CTA), magnetic resonance imaging (MRI) or digital subtraction angiography (DSA) by the WASID method (13). Symptomatic ICAD is defined as ischemic stroke or transient ischemic attack with clinical or radiological signs correspond to the vascular territory supplied by the disease vessel.
- •Patients with first-ever ischaemic stroke within 8 weeks of recruitment
排除标准
- •Patients who are unable to provide an informed consent
- •Patients who are contraindicated to contrast MRI scans, e.g. non-MRI compatible pacemaker, claustrophobia, known gadolinium-based contrast allergy, estimated glomerular filtration rate < 30mL/min/1.73m2, etc.
- •Patients who have absolute or relative contraindications to colchicine therapy, e.g. colchicine allergy, neuromuscular disorders, haematological diseases, chronic diarrhea, estimated glomerular filtration rate < 30mL/min/1.73m2, chronic liver disease, etc.
- •Patients with intracranial stenosis not due to atherosclerosis, e.g. vasculitis, vasospasm, Moyamoya disease, etc.
- •Patients with elevated creatine kinase level at randomisation stage of study.
- •Recurrent gouty arthritis that requires colchicine for > 3 months per year;
- •Inflammatory bowel disease or chronic diarrhea;
- •Neuromuscular disease or a nontransient creatine kinase level that was greater than three times the upper limit of the normal range (unless due to infarction) for > 3 months;
- •Clinically significant nontransient hematologic abnormalities with hemoglobin <10g/dL, white blood cell < 4x10^9, or platelet < 100x10^9/L for > 3 months;
- •Alcoholism;
- •Long term systemic glucocorticoid therapy
研究组 & 干预措施
Colchicine
0.5 mg of Colchicine for 12 months to be orally taken
干预措施: Colchicine 0.5 MG (Drug)
结局指标
主要结局
Regression of intracranial stenosis
时间窗: at 12 months
Regression in stenosis of ≥ 15% using the WASID method.
Regression of plaque volume
时间窗: at 12 months
Regression of plaque burden of ≥ 15% compared to baseline.
Major adverse cardio- or cerebrovascular events (MACE)
时间窗: at 12 months
Occurrence of any major adverse cardio- or cerebrovascular events (MACE).
次要结局
- Longitudinal changes in resolution of plaque enhancement(at 1,3,6,9,12 months)
- Longitudinal changes in plaque volume(at 1,3,6,9,12 months)
- Longitudinal changes in white matter hyperintensity volume(at 12 months)
- Longitudinal changes in number of silent lacunes(at 12 months)
- Longitudinal changes in ICAD stenosis(at 12 months)
- Longitudinal changes in cognitive ability(at 1,3,6,9,12 months)
研究者
Dr. IP Yiu Ming Bonaventure
Assistant Professor
Chinese University of Hong Kong