Role of Ripasudil in faster resolution of corneal edema in patients post cataract surgery
试验速览
- 阶段
- Unknown
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- To evaluate the potential of Ripasudil 0.4% in resolution of corneal edema postoperatively, to obtain corneal transparency.
研究概览
简要总结
Research indicates that ripasudil may improve the healing of corneal endothelial wounds in rabbit models(4), highlighting its potential for safeguarding the corneal endothelium during eye surgeries. Despite this, there is still no clear agreement on using ripasudil in human subjects to protect the cornea following intraocular surgeries. Recent findings (5) suggest that ripasudil could help maintain the functional integrity of the corneal endothelium and reduce cell loss after cataract surgery in patients with low endothelial cell density (ECD). These observations point to the possibility of employing ripasudil more broadly to protect the corneal endothelium after such procedures. The purpose of this study is to assess the effectiveness of ripasudil in preserving corneal ECD after standard cataract surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant, Investigator, Outcome Assessor and Date-entry Operator Blinded
入排标准
- 年龄范围
- 45.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •All patients undergoing cataract surgery- Phacoemulsification and small incision cataract surgery with any grade of corneal edema on post-operative Day 1.
排除标准
- 未提供
结局指标
主要结局
To evaluate the potential of Ripasudil 0.4% in resolution of corneal edema postoperatively, to obtain corneal transparency.
时间窗: every subject is followed up at the end of 1st week, 2nd week and 6th week
次要结局
- Compare the efficacy of ripasudil versus standard of care in treatment of postoperative corneal edema(all participants of the trial are followed up over 6 weeks)
研究者
Dr. Shubashree Karat
St Johns Medical College and Hospital