Efficacy of the Thai-strains probiotics and plant extracts on genitourinary symptoms and microbiome, blood glucose and lipids, and health-related quality of life in Thai menopausal women

Srinakharinwirot University0 个研究点目标入组 120 人开始时间: 2024年7月31日最近更新: 2024年8月19日

试验速览

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•1. Women aged 40 - 60 who have been in menopause (either naturally or following surgery to remove the uterus and ovaries) for at least 36 months (3 years) since their last menstruation.
•2. Meet at least one of the following criteria: have symptoms related to the genital system, urinary tract system, or sexual activity that occur after menopause, as assessed by the Menopause Rating Scale (MRS). They should not have received hormone replacement therapy before or have discontinued it for at least 6 months.
•3. Breast examination shows no lumps and initial internal examination finds no lumps in the cervix, uterus, or ovaries.
•4. No chronic diseases, including diabetes requiring medication, hypertension requiring medication, endocrine diseases like thyroid disorders, heart disease, liver disease, kidney disease, breast cancer, ovarian cancer, uterine cancer, or depression.
•5. No history of allergy to soy or soy derivatives.
•6. Willing to participate in the research project, including undergoing internal examinations, blood tests, laboratory tests, and ultrasound examinations, and able to attend follow-up appointments as scheduled.

•1. Volunteers who are treating a vaginal infection or urinary tract infection by taking antibiotics or who have recently stopped taking antibiotics for treating bacterial infections from other causes within the last 2 weeks.
•2. Have a history of severe adverse effects from using hormone replacement therapy, any soy-based products, and extracts from Dong Quai, Chameleon plant, or rosehip.
•3. Have a history of lumping the breast or an abnormal breast cancer screening result that has not been conclusively resolved.
•4. Have a history of abnormal bleeding or irregular menstruation within the past 36 months.
•5. Have a history of gastrointestinal symptoms, including gastritis, diarrhea, chronic constipation, or irritable bowel syndrome.

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