Randomized Controlled Trial to Evaluate of Dexmedetomidine for the Effect on Operative Visibility in Patients Undergoing Endoscopic Sinus Surgery
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- surgical satisfaction about visibility of operative field
研究概览
简要总结
Various maneuvers are commonly used to achieve the ideal operative field necessary for successful endoscopic sinus surgery (ESS). Dexmedetomidine, a potent alpha2 adrenoceptor agonist which dose-dependently reduces arterial blood pressure and heart rate, decreases the hemodynamic and catecholamine response. And dexmedetomidine has an effect of peripheral vasoconstriction thus it is thus theologically appropriate for reducing bleeding during intranasal operation.
The aim of this study is to compare the effect of dexmedetomidine, an alpha2-adrenoreceptor agonist, on intraoperative bleeding, propofol requirement and postoperative profiles to remifentanil , an ultrashort-acting opioid.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged between 20 and 70 year
- •General anesthesia for endoscopic sinus surgery
排除标准
- •Body mass index >30
- •Congestive heart failure, Sinus Bradycardia(<50 BPM), Uncontrolled hypertension,
- •Coagulopathy
- •Drug addiction
- •Pregnancy
- •Allergic fungal infection
研究组 & 干预措施
remifentanil
干预措施: propofol and remifentanil (Drug)
dexmedetomidine
干预措施: Propofol and dexmedetomidine (Drug)
结局指标
主要结局
surgical satisfaction about visibility of operative field
时间窗: Within 1 day of endoscopic sinus surgery finish including dressing of surgical wound
subjective satisfaction about visibility of operative field by surgeon/ numerous rating scale / 0: worst - 10:best
次要结局
未报告次要终点