NCT04082169Unknown不适用
Causes and Consequences of Primary Ovarian Insufficiency
Haukeland University Hospital1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2019年1月11日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Endocrine disrupting chemicals
研究概览
简要总结
100 women with primary ovarian insufficiency will be included for extensive diagnostic workup to improve diagnostic precision by extended autoantibody screening and genetic and toxicological testing.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women 40 years or younger, more than 4 months amenorrhea, more than 2 FSH measurements in menopausal range (drawn at least 2 months apart), ability to provide informed concent -
排除标准
- •History of oophorectomy, chemotherapy or radiation
结局指标
主要结局
Endocrine disrupting chemicals
时间窗: one day
Characterize the cohort of women with POI, including testing for environmental factors
Autoimmune
时间窗: one day
Prevalence of primary ovarian insufficiency (POI) with autoimmune etiology based on positive autoantibodies toward steroidogenic cells
Genetic
时间窗: one day
Prevalence of POI with genetic etiology defined by detection of genetic defects in a NGS panel
次要结局
- Phenotype description(one day)
研究者
研究点 (1)
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