Predisposing Factors Associated With Chemotherapy Toxicity in Elderly Cancer Patients: A Prospective Study
试验速览
- 阶段
- 不适用
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- predisposing factors of patients developed grade 3 or 4 chemotherapy toxicity
研究概览
简要总结
These days, there is higher proportion of elderly cancer patients. Most of them have comorbidities, borderline performance status and nutritional status. The discontinuation of chemotherapy due to unbearable toxicities was not uncommon. Comprehensive geriatric assessment might be beneficial in selection of suitable elderly patients for chemotherapy administration.
详细描述
The patients with the age more than 70 years old who scheduled for chemotherapy were enrolled. Geriatric assessment was performed before starting chemotherapy. The toxicity will be recorded prospectively. Predisposing factors of grade 3 and 4 toxicity will be reported.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 70 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •more than 70 years of age
- •plan to receive first cycle of chemotherapy
- •histologically or cytologically proved of cancer
排除标准
- •patients who have concurrent chemoradiotherapy
- •patients who received local chemotherapy
结局指标
主要结局
predisposing factors of patients developed grade 3 or 4 chemotherapy toxicity
时间窗: from starting chemotherapy to 1 month after last dose of chemotherapy
次要结局
- incidence of grade 3 or 4 chemotherapy toxicity in elderly(from starting chemotherapy to 1 month after last dose of chemotherapy)
- Factors associated with good quality of life during receiving chemotherapy(from starting chemotherapy to 1 month after last dose of chemotherapy)