A double blinded randomized controlled study comparing analgesic efficacy of Dexmedetomidine versus Buprenorphine versus Dexamethasone as an adjuvant to Bupivacaine in ultrasound guided combined tranversus abdominis plane block and rectus sheath block for postoperative pain relief in patients undergoing abdominal surgeries
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 87
- 试验地点
- 1
- 主要终点
- To compare the postoperative analgesic efficacy of dexmedetomidine versus buprenorphine versus dexamethasone in combined transversus abdominis plane block and rectus sheath block in abdominal surgeries in providing postoperative analgesia as measured by visual analogue scale and numeric rating scale at specific time intervals.
研究概览
简要总结
The main objective of this study is to compare analgesic efficacy between dexmedetomidine, buprenorphine and dexamethasone in ultrasound guided transversus abdominis plane block and rectus sheath block in providing postoperatvie analgesia to patients. As per new guidelines it is recommended to include a mode of regional anaesthesia in providing pain relief to patients wherever possible.
No study has compared the 3 drugs as adjuvants. Some drugs provide a faster onset of pain relief, some drugs might start their action late but can last longer. Hence with this study we can conclude which drugs can be used for short term as well as long term pain relief.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA GRADE 1 and 2 patients.
- •Patients undergoing elective abdominal surgeries.
- •Patients giving written informed consent.
排除标准
- •Age less than 18 years, Age greater than 65 years.
- •No genders are excluded.
- •Patient refusal to participate in the study.
- •Any contraindication to regional anaesthesia.
- •Patients with neurological or psychiatric problems.
- •Patient allergic to study drugs.
- •Patients with uncontrolled hypertension or bradycardia.
- •Patients on chronic opioid therapy and other pain medications.
- •ASA GRADES 3 and above.
结局指标
主要结局
To compare the postoperative analgesic efficacy of dexmedetomidine versus buprenorphine versus dexamethasone in combined transversus abdominis plane block and rectus sheath block in abdominal surgeries in providing postoperative analgesia as measured by visual analogue scale and numeric rating scale at specific time intervals.
时间窗: 30 minutes | 2 hours | 4 hours | 6 hours | 10 hours | 16 hours | 24 hours
次要结局
- To evaluate duration of analgesia in hours provided by each drug by assessing the time until the first dose of rescue analgesic is required postoperatively.(30 MINUTES)
- To compare the total amount of rescue analgesic administered in the first 24 hours post surgery among the 3 groups.(30 MINUTES)
- To assess the incidence of postoperative complications(30 MINUTES)
研究者
Manfred Francis Cardozo
Seth V.C Gandhi and M.A Vora Municipal General Hospital