Anatomical Resection in Colorectal Liver Metastases Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 729
- 主要终点
- RFS
研究概览
简要总结
The type of liver resection (anatomical resection, AR or nonanatomical resection, NAR) for colorectal liver metastases (CRLM) is subject to debate. The debate may persist because some certain prognostic factors, associated with aggressive biological behavior of tumor, have been overlooked. The aim of our study was to investigate the characteristics of patients who would benefit more from anatomical resection for colorectal liver metastases.
详细描述
729 patients who underwent hepatic resection of CRLM were retrospectively collected from June 2012and May 2019. Treatment effects between AR and NAR were compared in full subgroup analyses. Tumor relapse-free survival (RFS) was evaluated by a stratified log-rank test and summarized with the use of Kaplan-Meier and Cox proportional hazards methods.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •(1)Age 18-79 years;(2) Histologically proven colorectal adenocarcinoma;
排除标准
- •(1) the histologic type of tumor was not called adenocarcinoma; (2) peritoneal metastasis; (3) number of liver metastasis >3; (4) simultaneous anatomical and nonanatomical resections; (5) R2 resection; (6) history of previous hepatectomy; (7) incomplete data. The rest of patients were divided into 2 groups: patients undergoing an AR, and patients undergoing a NAR.
结局指标
主要结局
RFS
时间窗: 2012.6.1-2022.6.1
Relapse-free survival since patients undergoing hepatic resection
次要结局
- OS(2012.6.1-2022.6.1)
研究者
Xu jianmin
Head of Colorectal Surgery
Fudan University