The safety and efficacy of baclofen for alcohol dependence: a double-blind randomised placebo-controlled trial

Sydney South West Area Health Service0 个研究点目标入组 42 人开始时间: 2006年3月15日最近更新: 2020年1月13日

适应症

试验速览

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•DMS-IV criteria for alcohol dependence; Meets criteria for current heavy drinking; Can provide informed written consent; 3-days abstinence prior to treatment; Desires abstinence or to greatly reduce alcohol consumption; Has stable residence and can provide collateral contact details.

•Clinically significant medical disease that might interfere with the evaluation of the study medication or present a safety concern; Clinically significant psychiatric illness or substance use disorder other than alcohol or nicotine dependence or cannabis abuse; Concurrent use of any psyhotropic medication (except subjects on stable antidepressant doses > 2 months); Concurrent use of anticonvulsants, insulin or oral hypoglycemics, History of complicated alcohol withdrawal; Extremely abnormal LFTs; Women who are pregnant or breadfeeding; Requiring inpatient or more intense outpatient treatment for alcohol dependence; Court-mandated participation in alcohol treatment or impending incarceration.

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