Immune Tolerance Dysfunction in Pregnancy Due to Ambient Air Pollution
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Difference in immune cell subset identity and function in pregnant vs. non pregnant women exposed to high vs. low pollution over time
研究概览
简要总结
The purpose of this project is to study the effects of air pollution toxicants on pregnant mothers' immune health during and after pregnancy.
Using already collected samples, this study proposes to evaluate changes in immune function in response to air pollution with the use of innovative technologies, to identify the drivers of immune dysfunction and potential modifiable factors, and to determine how these immune findings are associated with pollution exposure and outcomes of disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Pregnant women: at 18-25 weeks gestation at time of eligibility screening and baseline visit
排除标准
- •Having smoked more than 50 cigarettes during pregnancy
- •A history of autoimmune diseases, HIV or cancer
结局指标
主要结局
Difference in immune cell subset identity and function in pregnant vs. non pregnant women exposed to high vs. low pollution over time
时间窗: 3 years
Identify the epigenetic molecular mechanisms driving immune dysfunction in pregnancy vs. no pregnancy with high vs. low PM2.5 exposure over time
时间窗: 3 years
Map T cell receptor diversity to immune dysfunction in pregnancy vs non pregnancy with high vs. low PM2.5 exposure over time
时间窗: 3 years
次要结局
未报告次要终点
研究者
R. Sharon Chinthrajah
Associate Professor of Medicine
Stanford University