Lymph Node Ratio and Kras Mutation in Risk Stratification of Colon Cancer
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 433
- 试验地点
- 1
- 主要终点
- LNR and K ras were evaluated with correlated with different clinicopathological parameters (Gender, CEA, tumor size, tumor grade and response to treatment).
研究概览
简要总结
clinical impact of LN ratio with Kras expression in colon cancer
详细描述
LNR and K ras were evaluated with correlated with different clinicopathological parameters of the patients, PFS and OS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 16 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Stage III colon cancer
排除标准
- •Stage I, II, IV
研究组 & 干预措施
patients
LNR measured by (number of metastatic lymph nodes/total number of lymph nodes excised). and K ras (polymerase chain reaction (PCR) and pyrosequencing targeted for KRAS codons 12-13 was performed )
干预措施: k ras (Device)
patients
LNR measured by (number of metastatic lymph nodes/total number of lymph nodes excised). and K ras (polymerase chain reaction (PCR) and pyrosequencing targeted for KRAS codons 12-13 was performed )
干预措施: Panitumumab (Drug)
结局指标
主要结局
LNR and K ras were evaluated with correlated with different clinicopathological parameters (Gender, CEA, tumor size, tumor grade and response to treatment).
时间窗: 2 years
impact on response
次要结局
- LNR and K ras were evaluated and ASSOCIATION with PFS and OS.(2 years)