A prospective observational Study evaluating the impact of combining the One-Hour Sepsis Bundle and Point-of-Care Ultrasound (POCUS) in Sepsis and Septic Shock Patients presenting to Emergency Department in a Tertiary Care Hospital, in Manipur

Sepsis and septic shock remain leading causes of morbidity and mortality worldwide. Early identification and prompt treatment are critical to improving outcomes.This thesis aims to evaluate the impact of combining the 1-hour sepsis bundle with POCUS in the management of sepsis and septic shock patients presenting to Emergency Department in a tertiary care hospital, assessing its effects on patient outcomes, time to intervention, and clinical decision-making The study will involve Patients presenting to the ED with suspected sepsis or septic shock based on clinical criteria (e.g. qSOFA,NEWS2 score).It is anticipated that the use of POCUS in conjunction with the 1-hour sepsis bundle will result in Quicker identification and treatment of sepsis, Improved fluid resuscitation and cardiac optimization, More efficient management of septic shock.Data will be analyzed using appropriate statistical methods, adjusting for confounders and handling missing data with multiple imputation. This study aims to evaluate the impact of combining the 1-hour sepsis bundle with POCUS in the management of sepsis and septic shock patients presenting to Emergency Department and results of the study may ultimately contribute to evidence-based guidelines in the field of Emergency Medicine.