Evaluation of SERPINA1 Gene Polymorphisms in COPD as a Risk Factor for Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- SERPINA1 gene polymorphism
研究概览
简要总结
Chronic obstructive pulmonary disease and periodontitis are chronic inflammatory diseases. The study aims to determine if the genetic polymorphism of SERPINA1 gene in patients with COPD serve as a risk factor for developing periodontitis.
详细描述
periodontitis is a polymicrobial inflammatory disease caused by various modifiable and non-modifiable risk factors. the non-modifiable risk factors include genetic polymorphisms like the gene coding for alpha-1-antitrypsinase
COPD is a chronic inflammatory disease characterized by deterioration of lung function due to loss of elasticity of the lungs.
SERPINA1 gene product has a protective role on the connective tissue components of both lungs and gums.
Hence, this study tries to determine if the gene polymorphism in COPD serves as a risk factor for developing periodontitis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male and female patients aged between 30-70yrs diagnosed with COPD and chronic periodontitis who are willing to participate in the study.
排除标准
- •Pateints with other systemic disorders
- •patients not willing to participate in the study
结局指标
主要结局
SERPINA1 gene polymorphism
时间窗: 9 months
of blood samples and running samples by PCR
次要结局
未报告次要终点
研究者
Dr.Sneha Agarwal
P.G student
Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre