NL-OMON34353已完成不适用
A randomised, double blind, placebo-controlled cross-over study to investigate the effects of intravenous S(+)-ketamine on functional brain connectivity using fMRI in healthy volunteers. - The F-KET Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •healthy volunteers
- •right handed
- •naive to Ketanest-S
排除标准
- •Obesity (BMI > 30);
- •Significant history of any cardiac or vascular disorder, asthma or other pulmonary disease, major gastrointestinal abnormalities, peptic ulceration, hepatic, neurological, psychiatric, haematological (including bleeding disorders), endocrine, renal, or major genitourinary disease.
- •History of illness, condition or medication use that, in the opinion of the investigator, might interfere with optimal participation, confound the results of the study or pose additional risk in administering S(+)-ketamine to the subject or in making the MRIs
- •History of chronic alcohol or illicit drug use;
- •Unable to refrain from quinine containing products and grapefruit or grapefruit juice from 7 days prior to study start until the last study day.
- •Metal medical devices like pacemakers, knee or hip prosthesis, ear implants, vessel clips, subcutaneous insulin pumps or carries metal particles (e.g. metal splinter in the eye) inside the body.
- •Claustrophobia.
- •Allergy to study medications;
- •Not able to maintain a regular diurnal rhythm.
研究者
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