OCTA to Quantify the Parapapillary Choroidal Microvascular Changes in High Myopia
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Parapapillary choroidal microvasculature void (MvV) area
研究概览
简要总结
Myopia is a global healthy concern, especially the high myopia and pathological myopia among Asian populations. However, its mechanism still remains largely unclear. Recent findings suggested choroidal changes might be related to the development of myopia. This study is to useOCT angiography (OCT-A) to investigate parapapillary choroidal microvasculature change in myopic eyes, and try to find the cause-and-effect relationship between choroidal change and the development of myopia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Spherical equivalent measurement can be included in above 4 groups
- •Willing to be followed up in the future 10 years
排除标准
- •Deny to sign the patient consent, or deny to be followed
- •Evidence of cardiac, or diabetic, or CNS disease.
- •Clinically diagnosed with retinal or choroidal disease
- •Cataract or corneal disease that influence the quality of fundus OCTA image
研究组 & 干预措施
Group 1/Control
Spherical equivalent: -2.00～+2.00 D
干预措施: Optic coherence tomography angiography (OCTA) (Device)
Group 1/Myopia
Spherical equivalent: -3.00～-6.00 D
干预措施: Optic coherence tomography angiography (OCTA) (Device)
Group 3/High
Spherical equivalent: -6.00～-10.00 D
干预措施: Optic coherence tomography angiography (OCTA) (Device)
Group 4/Super High
Spherical equivalent: <-10.00
干预措施: Optic coherence tomography angiography (OCTA) (Device)
结局指标
主要结局
Parapapillary choroidal microvasculature void (MvV) area
时间窗: changes of MvV area at 5 years
area of parapapillary choroidal microvasculature void on OCTA images
Parapapillary choroidal microvasculature void (MvV) area
时间窗: changes of MvV area from at 10 years
area of parapapillary choroidal microvasculature void on OCTA images
Parapapillary choroidal microvasculature void (MvV) area
时间窗: difference of MvV area in each group at baseline
area of parapapillary choroidal microvasculature void on OCTA images
Parapapillary choroidal microvasculature void (MvV) area
时间窗: changes of MvV area at 1 years
area of parapapillary choroidal microvasculature void on OCTA images
Parapapillary choroidal microvasculature void (MvV) area
时间窗: changes of MvV area at 3 years
area of parapapillary choroidal microvasculature void on OCTA images
次要结局
- Correlation coefficient between choroidal MvV and PPA area(baseline)
- Correlation coefficient between choroidal MvV and refractive power(baseline)
- MvV number(baseline)
- Correlation coefficient between choroidal MvV and RNFL thickness(baseline)
- Correlation coefficient between choroidal MvV and Axial length(baseline)
- Correlation coefficient between choroidal MvV and retinal parapapillary perfusion(baseline)
- Correlation coefficient between choroidal MvV and choroid thickness(baseline)
- Correlation coefficient between choroidal MvV and Macular perfusion(baseline)