NCT03296124撤回不适用
Prognostic Value of Androgen Receptor Expression and Mutations Within Oncogenes and Tumor Suppressor Genes in Patients Treated for High Risk Prostate Cancer With Proton Therapy
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Immunohistochemistry of tumor cell proteins will be performed on prostate biopsies to detect for androgen receptors and other protein products related to oncogenes or tumor suppressor genes thought to play a role in radiation or ADT.
研究概览
简要总结
Retrospective Review Study for Prognostic Transcriptional Output Related to Androgen Receptor Expression in Patients Treated for High Risk Prostate Cancer with Proton Therapy
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Adult patients (older than 18 years at time of treatment) with high risk prostate cancer who were treated with proton therapy at UFHPTI/Department of Radiation Oncology
- •Patients treated between 6/10/2010 through 4/26/17 with at least 2 years follow up
排除标准
- 未提供
结局指标
主要结局
Immunohistochemistry of tumor cell proteins will be performed on prostate biopsies to detect for androgen receptors and other protein products related to oncogenes or tumor suppressor genes thought to play a role in radiation or ADT.
时间窗: 2 years follow up
次要结局
- RNA sequencing will be performed on several oncogenes and tumor suppressor genes including genes coding androgen receptors to detect RNA expression including genes related to the androgen receptor.(2 years follow up)
- DNA sequencing will be performed on prostate tumor DNA to determine the mutational status of several oncogenes and tumor suppressor genes including genes coding androgen receptors.(2 years follow up)
研究者
研究点 (1)
Loading locations...
相似试验
招募中
不适用
Androgen Receptor, Implications for Health and Wellbeing: Natural History Study of Individuals With Androgen InsensitivityMetabolic Parameters in AIS, CAIS, PAIS and MAISTumor Formation in AIS, CAIS, PAIS and MAISSexual Function AIS, CAIS, PAIS and MAISAndrogen Insensitivity SyndromeNCT04708431Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)650
已完成
不适用
Androgen Receptor mRNA Expression is Positively Associated With Live Birth in Women Undergoing IVF Independently of the Type of Ovarian ResponseAndrogen Receptor Gene OverexpressionNormal RespondersPoor Ovarian ResponseBologna CriteriaNCT03433768Aristotle University Of Thessaloniki67
已完成
不适用
of Androgen Receptor Expression in Breast Cancer With or Without BRCA MutationBreast CancerNCT05404334Banaras Hindu University231
进行中（未招募）
1 期
Dynamics of Androgen Receptor.MedDRA version: 21.1Level: PTClassification code 10036909Term: Prostate cancer metastaticSystem Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)MedDRA version: 21.0Level: PTClassification code 10036920Term: Prostate cancer stage IVSystem Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)MedDRA version: 20.0Level: PTClassification code 10060862Term: Prostate cancerSystem Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)MedDRA version: 21.0Level: PTClassification code 10036911Term: Prostate cancer recurrentSystem Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)MedDRA version: 21.0Level: PTClassification code 10036912Term: Prostate cancer stage 0System Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)MedDRA version: 21.0Level: PTClassification code 10036917Term: Prostate cancer stage ISystem Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)MedDRA version: 21.0Level: PTClassification code 10036919Term: Prostate cancer stage IIISystem Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)MedDRA version: 21.0Level: PTClassification code 10036918Term: Prostate cancer stage IISystem Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)Prostate cancerEUCTR2014-000476-26-NLetherlands Cancer Institute50
尚未招募
2 期
Dynamics of Androgen Receptor genomics and transcriptomics after neoadjuvant androgen ablation (DARANA)prostate cancerprostate carcinoma10038597NL-OMON40287Antoni van Leeuwenhoek Ziekenhuis60