NCT01834430已完成3 期
Effects of Delayed Enteral Nutrition on Inflammatory Responses and Immune Function Competence in Critically Ill Patients With Prolonged Fasting
Nanjing PLA General Hospital0 个研究点目标入组 45 人开始时间: 2010年2月1日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 45
- 主要终点
- all cause mortality
研究概览
简要总结
Different studies suggest that early enteral nutrition (EEN) has benefits in reducing infectious complications, there is no data that addresses whether delayed enteral nutrition (EN) is detrimental and if it may have effects on inflammatory responses and immune function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •having a fasting time of more than 14 days
- •American Society of Anesthesiologists (ASA) physical status ranging between 1 and 3, and their condition allows enteral nutrition therapy.
排除标准
- •chronic renal failure (peritoneal or hemodialysis or creatinine > 2.5 mg/dl)
- •history of chronic obstructive pulmonary disease
- •hepatic dysfunction or cirrhosis or a bilirubin value > 3 mg/dl
- •metabolic diseases,severe anemia
- •blood coagulation dysfunction
- •pregnancy lactation
- •history of psychiatric illness
- •patients underwent immunosuppressive therapy
结局指标
主要结局
all cause mortality
时间窗: 28 days
次要结局
- organ failure(7 days)
研究者
Gao Tao
Clinical Professor
Nanjing PLA General Hospital
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