Does Gluten Sensitivity Play a Role in Development of Thyroiditis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 198
- 试验地点
- 2
- 主要终点
- Amount of fibrosis in thyroid tissue and measured level of anti-tTG levels in serum
研究概览
简要总结
Gluten sensitivity is the most common auto-immune disease associated with auto-immune thyroiditis. This association is through elevated anti-Tissue transglutaminase (Anti-tTG) levels both in Celiac disease and thyroiditis. In our study we tried to find if there is any correlation in between Anti-tTG and degree of fibrosis in thyroid tissue (Post-operative specimen).
详细描述
Most common auto-immune disease associated with Celiac disease is autoimmune thyroiditis. This association in between Celiac disease and aout-immune thyroiditis is related with asymptomatic rise in anti-tTG levels. In our study, we planned to show that if there is any correlation of thyroiditis related fibrosis in thyroid tissue with anti-tTG IgA ( immune-globulin A) and IgG (immune-globulin G).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 88 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Thyroiditis patients operated for any indication
排除标准
- •Patients with known IgA deficiency
结局指标
主要结局
Amount of fibrosis in thyroid tissue and measured level of anti-tTG levels in serum
时间窗: one day after operation
Degree of fibrosis was defined after painting of slides with masson trichrome as absent, mild, moderate semi-quantitatively.
Measurement of Anti-tTG levels in serum
时间窗: one day after operation
Amount of serum Anti-TG in IU/mL
次要结局
未报告次要终点
研究者
Gorkem Gundogan
MD, Senior Resident of General Surgery
Diskapi Yildirim Beyazit Education and Research Hospital