Study of the Validity of Intensive Care Cirrhosis Outcome Score (ICCO) in Predicting Outcome in Cirrhotic Patients Admitted to Intensive Care Unit.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Testing the validity of ICCO score in predicting mortality in critically ill patients with cirrhosis admitted to the ICU.
研究概览
简要总结
This study aims at calculating a specific score to cirrhotic patients admitted at ICU (ICCO score) and use this score to predict mortality and outcome for admitted patients.
详细描述
Liver cirrhosis is the final stage of chronic liver disease. It is characterized by an irreversible replacement of liver parenchyma with fibrotic tissue and regenerative nodules. The major causes of cirrhosis include hepatitis B virus and hepatitis C virus infection, alcohol-associated liver disease (ALD), and non-alcoholic fatty liver disease (NAFLD).
The prognosis of cirrhotic patients admitted to the ICU remains poor It was reported that the mortality rate of patients with cirrhosis admitted to an intensive care unit (ICU) due to organ dysfunction ranges from 34% to 69% depending on the cause of admission, the presence of organ failure (OF) and the severity of the underlying liver disease.
Several prognostic scoring systems have been used to assess patients with cirrhosis admitted to the ICU, general ICU mortality risk scores; such as the Sequential Organ Failure Assessment (SOFA) score and the Acute Physiology and Chronic Health Evaluation II (APACHE II) score, other liver specific scores such as Model of end stage liver disease (MELD) score.
These scores can be calculated immediately upon admission to the ICU (first 24 h) or during the first days of hospitalization, leading to an evolutionary assessment over this short period of time.
Intensive care cirrhotic outcome (ICCO) score is a new score that was introduced to predict mortality and ICU outcome in cirrhotic patients admitted to the ICU. with limited studies that test the validity of the score and compare it with the other well-known ICU scores.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (age ≥18 years) with cirrhosis admitted to the ICU.
- •Confirmed diagnosis of cirrhosis based on clinical, radiological, and/or histological criteria.
- •Need for intensive care management due to acute illness or complications related to cirrhosis.
排除标准
- •Patients without a confirmed diagnosis of cirrhosis.
- •Patients with acute liver failure not meeting criteria for cirrhosis.
- •Patients with incomplete data for calculating ICCO.
- •Patients transferred from another ICU.
- •Patients who refuse participation in the study.
结局指标
主要结局
Testing the validity of ICCO score in predicting mortality in critically ill patients with cirrhosis admitted to the ICU.
时间窗: baseline
ICCO score will be calculated to all participants based on the formula The ICCO score was 0.3707 + (0.0773 x bilirubin (mg/dl)) - (0.00849 x cholesterol (mg/dl)) -(0.0155 x creatinine clearance (ml/min)) + (0.1351 x lactate (mmol/l)). and then correlation between ICCO score and ICU mortality will be tested
次要结局
- Compare ICCO score with other established ICU scoring systems regarding their ability to predict mortality in ICU cirrhotic patients.(baseline)
- Evaluate the utility of ICCO score in guiding clinical decision-making and resource allocation in ICU settings.(baseline)
- Assess the correlation of ICCO score with severity of liver disease and other organ dysfunctions.(baseline)
研究者
Michael Mamdouh Nathan
principle investigator
Assiut University