NCT06408571Enrolling By Invitation不适用
Study on the Pathogenesis of Retinal Vascular Diseases Based on Body Fluid Metabolomics
Zhongnan Hospital1 个研究点 分布在 1 个国家目标入组 3,900 人开始时间: 2023年9月7日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 3,900
- 试验地点
- 1
- 主要终点
- Screening of prognostic markers and model validation
研究概览
简要总结
Through the analysis of metabolites in body fluids (intraocular fluid, plasma) of patients with retinal vascular diseases (retinal vein occlusion, diabetic retinopathy), the possible pathogenesis of retinal vein occlusion was explored.
详细描述
- Clinical data of patients with RVO and DR Were retrospectively studied to analyze their pathogenesis. 2. Metabolomic studies were conducted on body fluids (intraocular fluid and peripheral blood) of patients with RVO and DR And control group to find out the differences and find new targets for the prevention and treatment of RVO and DR.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥18 years old
- •Confirmed diagnosis of retinal vein obstruction and diabetic retinopathy through ophthalmic specialist examination
排除标准
- •Severe systemic diseases
- •Pregnant and lactating patients
结局指标
主要结局
Screening of prognostic markers and model validation
时间窗: 1/12/2024-30/12/2024
1. Surface markers and key molecules related to the study of diseases were screened out, and a biomarker model for assessing disease prognosis was established. 2. Candidate differential molecules were screened through a training cohort, a Cox regression model was constructed, and the prognostic value of the model was verified in the test cohort.
次要结局
未报告次要终点
研究者
研究点 (1)
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